Phenotypes associated with this allele

• Allele Symbol: Tex12^tm1Hoog
• Allele Name: targeted mutation 1, Christer Hoog
• Allele ID: MGI:3811722
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tex12^tm1Hoog/Tex12^tm1Hoog	involves: 129S2/SvPas	MGI:3811736

Genotype
MGI:3811736

hm1

• Allelic Composition: Tex12^tm1Hoog/Tex12^tm1Hoog
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased oocyte number ( J:139993 )

♀ • only 30% of oocytes are present at E16.5

♀ • however, oocyte density is normal

oocyte degeneration ( J:139993 )

♀ • oocytes fail to form healthy primordial follicles and eventually degenerate

abnormal chiasmata formation ( J:139993 )

• meiotic chromosomes only partially synapse

• double-strand breaks during meiosis fail to develop into meiotic crossovers unlike in wild type oocytes

abnormal female meiosis ( J:139993 )

♀ • double-strand breaks during meiosis fail to develop into meiotic crossovers unlike in wild type oocytes

abnormal male meiosis ( J:139993 )

♂ • spermatocytes fail to form an XY body unlike in wild-type spermatocytes

reproductive system

decreased oocyte number ( J:139993 )

♀ • only 30% of oocytes are present at E16.5

♀ • however, oocyte density is normal

oocyte degeneration ( J:139993 )

♀ • oocytes fail to form healthy primordial follicles and eventually degenerate

abnormal chiasmata formation ( J:139993 )

• meiotic chromosomes only partially synapse

• double-strand breaks during meiosis fail to develop into meiotic crossovers unlike in wild type oocytes

abnormal female meiosis ( J:139993 )

♀ • double-strand breaks during meiosis fail to develop into meiotic crossovers unlike in wild type oocytes

abnormal male meiosis ( J:139993 )

♂ • spermatocytes fail to form an XY body unlike in wild-type spermatocytes

absent primordial ovarian follicles ( J:139993 )

♀ • oocytes fail to form healthy primordial follicles

absent ovarian follicles ( J:139993 )

♀ • hardly any follicles are present 1 week after birth

small ovary ( J:139993 )

♀

arrest of spermatogenesis ( J:139993 )

♂ • at the epithelial stage IV

female infertility ( J:139993 )

♀

male infertility ( J:139993 )

♂

endocrine/exocrine glands

absent primordial ovarian follicles ( J:139993 )

♀ • oocytes fail to form healthy primordial follicles

absent ovarian follicles ( J:139993 )

♀ • hardly any follicles are present 1 week after birth

small ovary ( J:139993 )

♀