Phenotypes associated with this allele

• Allele Symbol: Irf1^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:3811824
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf1^M1Btlr/Irf1^M1Btlr	C57BL/6J-Irf1^M1Btlr	MGI:4821095
ht2	Irf1^M1Btlr/Irf1^+	C57BL/6J-Irf1^M1Btlr	MGI:4821110

Genotype
MGI:4821095

hm1

• Allelic Composition: Irf1^M1Btlr/Irf1^M1Btlr
• Genetic Background: C57BL/6J-Irf1^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:162995 )

N • the blood of mutant mice contains normal numbers of CD4⁺ T cells, CD19⁺ B cells and CD11c⁺ dendritic cells

decreased NK cell number ( J:162995 )

• the blood of homozygous mutant mice contains a greatly reduced number of NK1.1⁺ cells

decreased CD8-positive, alpha-beta T cell number ( J:162995 )

• the bloood of homozygous mutant mice contains a greatly reduced number of CD8⁺ T cells

impaired natural killer cell mediated cytotoxicity ( J:162995 )

• natural killer (NK) cells from previously immunized homozygous mutant mice exhibit diminished ability to kill class I MHC-deficient cells in vivo

immune system

immune system phenotype ( J:162995 )

N • the blood of mutant mice contains normal numbers of CD4⁺ T cells, CD19⁺ B cells and CD11c⁺ dendritic cells

N • CD8⁺ cytotoxic T lymphocytes (CTL) from previously immunized mice exhibit normal ability to kill antigen-specific target cells in vivo

N • a normal tumor necrosis factor (TNF) alpha response is evoked by all toll-like receptor (TLR) ligands tested in peritoneal macrophages from mutant mice

decreased NK cell number ( J:162995 )

• the blood of homozygous mutant mice contains a greatly reduced number of NK1.1⁺ cells

decreased CD8-positive, alpha-beta T cell number ( J:162995 )

• the bloood of homozygous mutant mice contains a greatly reduced number of CD8⁺ T cells

impaired natural killer cell mediated cytotoxicity ( J:162995 )

• natural killer (NK) cells from previously immunized homozygous mutant mice exhibit diminished ability to kill class I MHC-deficient cells in vivo

decreased interferon-alpha secretion ( J:162995 )

• the TLR4 ligand, lipopolysaccharide (LPS), evokes a reduced type I interferon response in peritoneal macrophages from homozygous mutant mice

• the TLR3 ligand, poly I:C, evokes a reduced type I interferon (IFN) response in peritoneal macrophages isolated from homozygous mutant mice

decreased interferon-beta secretion ( J:162995 )

• the TLR4 ligant, lipopolysaccharide (LPS), evokes a reduced type I interferon response in peritoneal macrophages from homozygous mutant mice.

• the TLR3 ligand, poly I:C, evokes a lower than normal type I interferon (IFN) response in peritoneal macrophages isolated from homozygous mutant mice

increased susceptibility to Herpesvirales infection ( J:162995 )

• homozygous mutants exhibit enhanced susceptibility to infection with 2 x 10⁵ PFU of mouse cytomegalovirus (MCMV)

Genotype
MGI:4821110

ht2

• Allelic Composition: Irf1^M1Btlr/Irf1⁺
• Genetic Background: C57BL/6J-Irf1^M1Btlr

hematopoietic system

hematopoietic system phenotype ( J:162995 )

N • the blood of both homozygous and heterozygous mutant mice contains normal numbers of CD4⁺ T cells, CD19⁺ B cells and CD11c⁺ dendritic cells

decreased NK cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of NK1.1⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

decreased CD8-positive, alpha-beta T cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of CD8⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

impaired natural killer cell mediated cytotoxicity ( J:162995 )

• natural killer (NK) cells from previously immunized heterozygous mutant mice exhibit diminished ability to kill class I MHC-deficient cells in vivo; the level of killing is intermediate between that of wild-type and of homozygous mutant mice

immune system

immune system phenotype ( J:162995 )

N • the blood of both homozygous and heterozygous mutant mice contains normal numbers of CD4⁺ T cells, CD19⁺ B cells and CD11c⁺ dendritic cells

N • CD8⁺ cytotoxic T lymphocytes (CTL) from previously immunized homozygus and heterozygous mutant mice exhibit normal ability of to kill antigen-specific target cells in vivo

decreased NK cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of NK1.1⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

decreased CD8-positive, alpha-beta T cell number ( J:162995 )

• the bloood of heterozygous mutant mice contains a reduced number of CD8⁺ cells, intermediate between those of wild-type and of homozygous mutant mice

impaired natural killer cell mediated cytotoxicity ( J:162995 )

• natural killer (NK) cells from previously immunized heterozygous mutant mice exhibit diminished ability to kill class I MHC-deficient cells in vivo; the level of killing is intermediate between that of wild-type and of homozygous mutant mice

increased susceptibility to Herpesvirales infection ( J:162995 )

• heterozygous mutants exhibit enhanced susceptibility to infection with 2 x 10⁵ PFU of mouse cytomegalovirus (MCMV)