Phenotypes associated with this allele

• Allele Symbol: Hsd17b7^tm1Gibo
• Allele Name: targeted mutation 1, Geula Gibori
• Allele ID: MGI:3811923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo	involves: 129S1/Sv * C57BL/6	MGI:3812001

Genotype
MGI:3812001

hm1

• Allelic Composition: Hsd17b7^tm1Gibo/Hsd17b7^tm1Gibo
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:140055 )

• embryos die around E10.5-E11.5

• on E11.5, most embryos are undergoing resorption with severe disintegration

growth/size/body

decreased embryo size ( J:140055 )

• embryos are smaller in size at E10.5 than controls

embryo

decreased embryo size ( J:140055 )

• embryos are smaller in size at E10.5 than controls

pale yolk sac ( J:140055 )

• lack of vascularization is noted in the yolk sac of E10.5 embryos

cardiovascular system

abnormal vasculogenesis ( J:140055 )

• lack of vascularization is noted in the E10.5 fetus

abnormal heart morphology ( J:140055 )

• heart defects are noted in E10.5 embryos

pericardial effusion ( J:140055 )

• occurs in E10.5 embryos

homeostasis/metabolism

pericardial effusion ( J:140055 )

• occurs in E10.5 embryos

nervous system

abnormal brain development ( J:140055 )

• the boundary between the forebrain and the midbrain is poorly defined in E10.5 embryos

small embryonic telencephalon ( J:140055 )

• there is a marked underdevelopment and a reduction in the size and volume of the telencephalic vesicles in E10.5 embryos

• the boundary between the forebrain and the midbrain is poorly defined in these embryos

abnormal midbrain-hindbrain boundary development ( J:140055 )

• boundaries for the midbrain are poorly defined

decreased hindbrain size ( J:140055 )

• reduction in the size and volume of the hindbrain in E10.5 embryos

hindbrain hypoplasia ( J:140055 )

• marked underdevelopment of the hindbrain in E10.5 embryos

decreased midbrain size ( J:140055 )

• reduction in the size and volume of the midbrain in E10.5 embryos

midbrain hypoplasia ( J:140055 )

• marked underdevelopment of the midbrain in E10.5 embryos