Phenotypes associated with this allele

• Allele Symbol: Itsn1^tm2.1Mapr
• Allele Name: targeted mutation 2.1, Melanie A Pritchard
• Allele ID: MGI:3812035
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itsn1^tm2.1Mapr/Itsn1^tm2.1Mapr	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:3812071

Genotype
MGI:3812071

hm1

• Allelic Composition: Itsn1^tm2.1Mapr/Itsn1^tm2.1Mapr
• Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:140030 )

• 12% of mice die between 3 and 8 weeks of age

• however, remaining mice are develop normally and are fertile

premature death ( J:140030 )

• 12% of mice die between 3 and 8 weeks of age

growth/size/body

decreased body size ( J:140030 )

• after birth, 12% of mice exhibit reduced body size compared to wild-type mice

postnatal growth retardation ( J:140030 )

• 12% of mice exhibit a failure to thrive

nervous system

abnormal synaptic vesicle recycling ( J:140030 )

• in otherwise healthy mice, endocytotic rates of neuronal cells are decreased compared to in wild-type mice indicating a decrease in vesicle recycling

endocrine/exocrine glands

abnormal adrenal gland secretion ( J:140030 )

• in otherwise healthy mice, exocytosis rates from chromaffin cells is decreased compared to in wild-type mice

cellular

abnormal cell morphology ( J:140030 )

• mice that fail to thrive exhibit enlargement of early endosome in the brain unlike in wild-type mice