Phenotypes associated with this allele

• Allele Symbol: Chek2^tm1Pjs
• Allele Name: targeted mutation 1, Peter J Stambrook
• Allele ID: MGI:3812090
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chek2^tm1Pjs/Chek2^tm1Pjs	involves: 129/Sv * Black Swiss * FVB/N	MGI:3812107

Genotype
MGI:3812107

hm1

• Allelic Composition: Chek2^tm1Pjs/Chek2^tm1Pjs
• Genetic Background: involves: 129/Sv * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

polyploidy ( J:118262 )

• 8% of mouse embryonic fibroblasts are polyploidy

abnormal cell physiology ( J:118262 )

• mice embryonic fibroblasts exhibit constitutively activated DNA damage response

abnormal cell cycle ( J:118262 )

• mouse embryonic fibroblasts exhibit fewer cells with G1 DNA content, increased number of cells in S-phase and increased cells with G2 DNA content compared to wild-type cells whether or not cells are irradiated