Analysis Tools
growth/size/body
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• mice with this mutation are significantly heavier than normal at 8 and 12 weeks; at 17 weeks, the male founder mouse weighed 57.6 g
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hematopoietic system
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• elevated HbA1c was reported in progeny of the founder mouse at 11 and 16 weeks of age
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homeostasis/metabolism
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• elevated HbA1c was reported in progeny of the founder mouse at 11 and 16 weeks of age
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• at 19 weeks of age, the founder mouse had a serum glucose level of 541.5 mg/dL; hyperglycemia was reported in progeny of the founder mouse at 11 and 16 weeks
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• progeny of the founder mouse exhibit hyperinsulinemia
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• glucosuria was detected in the founder mouse at 19 weeks (score = 4), and in his progeny at 10 and 15 weeks
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• progeny of the index mouse exhibit insulin resistance
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renal/urinary system
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• glucosuria was detected in the founder mouse at 19 weeks (score = 4), and in his progeny at 10 and 15 weeks
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