Phenotypes associated with this allele

• Allele Symbol: Tg(TcraB12,TcrbB12)1Rest
• Allele Name: transgene insertion 1, Nicholas Restifo
• Allele ID: MGI:3812191
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rag1^tm1Mom/Rag1^tm1Mom Slc46a2^tm1Moki/Slc46a2^+ Tg(TcraB12,TcrbB12)1Rest/0	involves: 129 * C57BL/6	MGI:3812196

Genotype
MGI:3812196

cx1

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Slc46a2^tm1Moki/Slc46a2⁺; Tg(TcraB12,TcrbB12)1Rest/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:140121 )

• massive cell death of double negative as well as CD4⁺ and/or CD8⁺ thymocytes occur in these mice

thymus hypoplasia ( J:140121 )

• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice

decreased double-positive T cell number ( J:140121 )

• double-positive T cells are absent in the thymus

arrested T cell differentiation ( J:140121 )

• T cells are arrested in the DN3 stage

hematopoietic system

increased T cell apoptosis ( J:140121 )

• massive cell death of double negative as well as CD4⁺ and/or CD8⁺ thymocytes occur in these mice

thymus hypoplasia ( J:140121 )

• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice

decreased double-positive T cell number ( J:140121 )

• double-positive T cells are absent in the thymus

arrested T cell differentiation ( J:140121 )

• T cells are arrested in the DN3 stage

cellular

increased T cell apoptosis ( J:140121 )

• massive cell death of double negative as well as CD4⁺ and/or CD8⁺ thymocytes occur in these mice

endocrine/exocrine glands

thymus hypoplasia ( J:140121 )

• thymic cellularity is reduced by about 5-fold compared to transgenic Rag1 null mice