About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp3tm1(cre)Saka
targeted mutation 1, Shimon Sakaguchi
MGI:3812203
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctla4tm1Saka/Ctla4tm1Saka
Foxp3tm1(cre)Saka/Y
involves: BALB/c MGI:3812320
ot2
Foxp3tm1(cre)Saka/Y involves: BALB/c MGI:3812319


Genotype
MGI:3812320
cn1
Allelic
Composition
Ctla4tm1Saka/Ctla4tm1Saka
Foxp3tm1(cre)Saka/Y
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1Saka mutation (0 available); any Ctla4 mutation (54 available)
Foxp3tm1(cre)Saka mutation (0 available); any Foxp3 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are healthy until 7 weeks of age when they rapidly become moribund and begin to develop general edema that is frequently accompanied by ascites
• the cause of this sudden death may be myocarditis
• all mice die by 72 days of age

immune system
• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
• the frequency and absolute number of Foxp3+ CD4+ T cells are increased in the spleens and lymph nodes
• almost half of CD4+ T cells found in the spleen and lymph nodes also express Foxp3 compared to under 20% of CD4+ T cells in wild-type mice
• there are more than 5-fold greater numbers of Foxp3+ CD4+ T cells in the spleen and lymph nodes of these mice compared to controls
• the CD4+:CD8+ T cell ratio is greater in these mice than in controls
• mice have a several hundred fold increase in their sera levels of IgE
• mice have about a 3-fold increase in their sera levels of IgG
• regulatory T cells have diminished suppressive capabilities as measured by co-culturing with responder T cells activated by the presence of dendritic cells and anti_TCR antibody
• lymph nodes of 6-10 week old mice are visibly larger and have a greater than 5-fold increase in the number of cells
• there is an increased frequency of IFN-gamma producing Foxp3- CD4+ T cells in both spleen and lymph nodes
• there is an increased frequency of IL-2 producing Foxp3- CD4+ T cells in both spleen and lymph nodes
• there is an increased frequency of IL-4 producing Foxp3- CD4+ T cells in both spleen and lymph nodes
• antiparietal autoantibodies are readily detected in the sera
• mononuclear cells are densely infiltrated into the myocardium and appear to be destroying myocytes in affected individuals
• focal lymphocyte infiltrations occur in the salivary glands
• mice suffer from gastritis with various degrees of destruction of the gastric parietal cells and chief cells
• antiparietal autoantibodies are readily detected in the sera
• focal lymphocyte infiltrations occur in the lung

cardiovascular system
• hearts are visibly larger in moribund mice compared to wild-type controls
• mononuclear cells are densely infiltrated into the myocardium and appear to be destroying myocytes in affected individuals

digestive/alimentary system
• focal lymphocyte infiltrations occur in the salivary glands
• mice suffer from gastritis with various degrees of destruction of the gastric parietal cells and chief cells
• antiparietal autoantibodies are readily detected in the sera

endocrine/exocrine glands
• focal lymphocyte infiltrations occur in the salivary glands

respiratory system
• focal lymphocyte infiltrations occur in the lung

liver/biliary system
• congestion of the liver is evident in terminal cases

hematopoietic system
• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
• the frequency and absolute number of Foxp3+ CD4+ T cells are increased in the spleens and lymph nodes
• almost half of CD4+ T cells found in the spleen and lymph nodes also express Foxp3 compared to under 20% of CD4+ T cells in wild-type mice
• there are more than 5-fold greater numbers of Foxp3+ CD4+ T cells in the spleen and lymph nodes of these mice compared to controls
• the CD4+:CD8+ T cell ratio is greater in these mice than in controls
• mice have a several hundred fold increase in their sera levels of IgE
• mice have about a 3-fold increase in their sera levels of IgG
• regulatory T cells have diminished suppressive capabilities as measured by co-culturing with responder T cells activated by the presence of dendritic cells and anti_TCR antibody

growth/size/body
• hearts are visibly larger in moribund mice compared to wild-type controls
• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells




Genotype
MGI:3812319
ot2
Allelic
Composition
Foxp3tm1(cre)Saka/Y
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1(cre)Saka mutation (0 available); any Foxp3 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• gastric lesions are detectable in 2 out of 11 mice
• antiparietal autoantibodies are detected in the sera of 4 out of a 11 mice, including two mice that have gastric lesions

digestive/alimentary system
• gastric lesions are detectable in 2 out of 11 mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory