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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxp3tm1(cre)Saka
targeted mutation 1, Shimon Sakaguchi
MGI:3812203
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ctla4tm1Saka/Ctla4tm1Saka
Foxp3tm1(cre)Saka/Y
involves: BALB/c MGI:3812320
ot2
Foxp3tm1(cre)Saka/Y involves: BALB/c MGI:3812319


Genotype
MGI:3812320
cn1
Allelic
Composition
Ctla4tm1Saka/Ctla4tm1Saka
Foxp3tm1(cre)Saka/Y
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctla4tm1Saka mutation (0 available); any Ctla4 mutation (54 available)
Foxp3tm1(cre)Saka mutation (0 available); any Foxp3 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are healthy until 7 weeks of age when they rapidly become moribund and begin to develop general edema that is frequently accompanied by ascites
• the cause of this sudden death may be myocarditis
• all mice die by 72 days of age

immune system
• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
• the frequency and absolute number of Foxp3+ CD4+ T cells are increased in the spleens and lymph nodes
• almost half of CD4+ T cells found in the spleen and lymph nodes also express Foxp3 compared to under 20% of CD4+ T cells in wild-type mice
• there are more than 5-fold greater numbers of Foxp3+ CD4+ T cells in the spleen and lymph nodes of these mice compared to controls
• the CD4+:CD8+ T cell ratio is greater in these mice than in controls
• mice have a several hundred fold increase in their sera levels of IgE
• mice have about a 3-fold increase in their sera levels of IgG
• regulatory T cells have diminished suppressive capabilities as measured by co-culturing with responder T cells activated by the presence of dendritic cells and anti_TCR antibody
• lymph nodes of 6-10 week old mice are visibly larger and have a greater than 5-fold increase in the number of cells
• there is an increased frequency of IFN-gamma producing Foxp3- CD4+ T cells in both spleen and lymph nodes
• there is an increased frequency of IL-2 producing Foxp3- CD4+ T cells in both spleen and lymph nodes
• there is an increased frequency of IL-4 producing Foxp3- CD4+ T cells in both spleen and lymph nodes
• antiparietal autoantibodies are readily detected in the sera
• mononuclear cells are densely infiltrated into the myocardium and appear to be destroying myocytes in affected individuals
• focal lymphocyte infiltrations occur in the salivary glands
• mice suffer from gastritis with various degrees of destruction of the gastric parietal cells and chief cells
• antiparietal autoantibodies are readily detected in the sera
• focal lymphocyte infiltrations occur in the lung

cardiovascular system
• hearts are visibly larger in moribund mice compared to wild-type controls
• mononuclear cells are densely infiltrated into the myocardium and appear to be destroying myocytes in affected individuals

digestive/alimentary system
• focal lymphocyte infiltrations occur in the salivary glands
• mice suffer from gastritis with various degrees of destruction of the gastric parietal cells and chief cells
• antiparietal autoantibodies are readily detected in the sera

endocrine/exocrine glands
• focal lymphocyte infiltrations occur in the salivary glands

respiratory system
• focal lymphocyte infiltrations occur in the lung

liver/biliary system
• congestion of the liver is evident in terminal cases

hematopoietic system
• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
• the frequency and absolute number of Foxp3+ CD4+ T cells are increased in the spleens and lymph nodes
• almost half of CD4+ T cells found in the spleen and lymph nodes also express Foxp3 compared to under 20% of CD4+ T cells in wild-type mice
• there are more than 5-fold greater numbers of Foxp3+ CD4+ T cells in the spleen and lymph nodes of these mice compared to controls
• the CD4+:CD8+ T cell ratio is greater in these mice than in controls
• mice have a several hundred fold increase in their sera levels of IgE
• mice have about a 3-fold increase in their sera levels of IgG
• regulatory T cells have diminished suppressive capabilities as measured by co-culturing with responder T cells activated by the presence of dendritic cells and anti_TCR antibody

growth/size/body
• hearts are visibly larger in moribund mice compared to wild-type controls
• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells




Genotype
MGI:3812319
ot2
Allelic
Composition
Foxp3tm1(cre)Saka/Y
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1(cre)Saka mutation (0 available); any Foxp3 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• gastric lesions are detectable in 2 out of 11 mice
• antiparietal autoantibodies are detected in the sera of 4 out of a 11 mice, including two mice that have gastric lesions

digestive/alimentary system
• gastric lesions are detectable in 2 out of 11 mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory