Analysis Tools
mortality/aging
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• mice are healthy until 7 weeks of age when they rapidly become moribund and begin to develop general edema that is frequently accompanied by ascites
• the cause of this sudden death may be myocarditis
• all mice die by 72 days of age
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immune system
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• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
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• the frequency and absolute number of Foxp3+ CD4+ T cells are increased in the spleens and lymph nodes
• almost half of CD4+ T cells found in the spleen and lymph nodes also express Foxp3 compared to under 20% of CD4+ T cells in wild-type mice
• there are more than 5-fold greater numbers of Foxp3+ CD4+ T cells in the spleen and lymph nodes of these mice compared to controls
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• the CD4+:CD8+ T cell ratio is greater in these mice than in controls
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• mice have a several hundred fold increase in their sera levels of IgE
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• mice have about a 3-fold increase in their sera levels of IgG
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• regulatory T cells have diminished suppressive capabilities as measured by co-culturing with responder T cells activated by the presence of dendritic cells and anti_TCR antibody
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• lymph nodes of 6-10 week old mice are visibly larger and have a greater than 5-fold increase in the number of cells
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• there is an increased frequency of IFN-gamma producing Foxp3- CD4+ T cells in both spleen and lymph nodes
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• there is an increased frequency of IL-2 producing Foxp3- CD4+ T cells in both spleen and lymph nodes
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• there is an increased frequency of IL-4 producing Foxp3- CD4+ T cells in both spleen and lymph nodes
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• antiparietal autoantibodies are readily detected in the sera
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myocarditis
(
J:140085
)
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• mononuclear cells are densely infiltrated into the myocardium and appear to be destroying myocytes in affected individuals
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• focal lymphocyte infiltrations occur in the salivary glands
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• mice suffer from gastritis with various degrees of destruction of the gastric parietal cells and chief cells
• antiparietal autoantibodies are readily detected in the sera
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• focal lymphocyte infiltrations occur in the lung
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cardiovascular system
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• hearts are visibly larger in moribund mice compared to wild-type controls
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myocarditis
(
J:140085
)
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• mononuclear cells are densely infiltrated into the myocardium and appear to be destroying myocytes in affected individuals
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digestive/alimentary system
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• focal lymphocyte infiltrations occur in the salivary glands
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• mice suffer from gastritis with various degrees of destruction of the gastric parietal cells and chief cells
• antiparietal autoantibodies are readily detected in the sera
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endocrine/exocrine glands
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• focal lymphocyte infiltrations occur in the salivary glands
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respiratory system
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• focal lymphocyte infiltrations occur in the lung
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liver/biliary system
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• congestion of the liver is evident in terminal cases
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hematopoietic system
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• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
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• the frequency and absolute number of Foxp3+ CD4+ T cells are increased in the spleens and lymph nodes
• almost half of CD4+ T cells found in the spleen and lymph nodes also express Foxp3 compared to under 20% of CD4+ T cells in wild-type mice
• there are more than 5-fold greater numbers of Foxp3+ CD4+ T cells in the spleen and lymph nodes of these mice compared to controls
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• the CD4+:CD8+ T cell ratio is greater in these mice than in controls
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• mice have a several hundred fold increase in their sera levels of IgE
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• mice have about a 3-fold increase in their sera levels of IgG
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• regulatory T cells have diminished suppressive capabilities as measured by co-culturing with responder T cells activated by the presence of dendritic cells and anti_TCR antibody
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growth/size/body
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• hearts are visibly larger in moribund mice compared to wild-type controls
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• spleens of 6-10 week old mice are visibly larger and have a greater than 3-fold increase in the number of cells
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