Analysis Tools
cardiovascular system
|
• the volume of the atrioventricular node is reduced by about a third compared to controls 8 weeks after cre induction
|
|
• sinus node tachycardia is noted in about 17% of mice that have had cre expression induced
• sinus bradycardia is observed in about a third of the mice that have had cre expression induced
• long term monitoring of mice indicates a general increase in heart rate in the weeks after induction of cre
|
|
• the prolongation of the PR interval is a hallmark of atrioventricular block
• partial failure of AV conduction (25%) or total dissociation of atrial and ventricular rhythms (37.5%) occurs by 4 weeks after cre induction
• half of the mice have accelerated junctional rhythms that originate in the AV node
• not all the excitations successfully traverse the AV node at slower heart rates (i.e. increased Wenckebach periodity)
• dye-coupling experiments reveals leakiness between cardiomyocytes starting three weeks after cre induction
|
|
• mice have a prolonged PR-interval after induction of cre expression
• the length of the interval increases the longer after induction of cre
• by 4 weeks after induction of cre, the length of the interval has more than doubled
|
muscle
|
• the volume of the atrioventricular node is reduced by about a third compared to controls 8 weeks after cre induction
|
