Phenotypes associated with this allele

• Allele Symbol: Tg(Alb-REG3A)24Lchr
• Allele Name: transgene insertion 24, Laurence Christa
• Allele ID: MGI:3812483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Alb-REG3A)24Lchr/0	involves: C57BL/6 * CBA	MGI:3812508

Genotype
MGI:3812508

tg1

• Allelic Composition: Tg(Alb-REG3A)24Lchr/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver physiology ( J:84698 )

• hepatocytes are resistant to TNF-alpha + ActD induced apoptosis

increased hepatocyte proliferation ( J:84698 , J:140235 )

• following stimulation with EGF in culture (J:84698)

• following two thirds partial hepatectomy (J:140235)

enhanced liver regeneration ( J:84698 )

• following partial hepatectomy, mice exhibit a greater increase in the number of proliferating cells in the liver compared to similarly treated wild-type mice

• following partial hepatectomy, livers exhibit increased weight at 48, 60, 72 and 96 hours post-surgery compared to similarly treated wild-type mice

• however, by 120 hrs post partial hepatectomy liver weights are normal

homeostasis/metabolism

decreased susceptibility to injury ( J:140235 )

• mice are less susceptible to fulminant hepatitis induced by J0-2 than wild-type mice as indicated by increased survival

cellular

increased hepatocyte proliferation ( J:84698 , J:140235 )

• following stimulation with EGF in culture (J:84698)

• following two thirds partial hepatectomy (J:140235)