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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		InsrRgsc824
RIKEN Genomic Sciences Center (GSC), 824
MGI:3812540
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		InsrRgsc824/Insr+ involves: C57BL/6JJcl * DBA/2JJcl MGI:3812548


Genotype
MGI:3812548
ht1
Allelic
Composition		 InsrRgsc824/Insr+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
InsrRgsc824 mutation (1 available); any Insr mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased glycosylated hemoglobin level ( J:133634 )
• at 11 weeks of age, the founder mouse had an HbA1c of 11.5%

homeostasis/metabolism
increased glycosylated hemoglobin level ( J:133634 )
• at 11 weeks of age, the founder mouse had an HbA1c of 11.5%
hyperglycemia ( J:133634 )
• at 11 weeks of age, the founder mouse had a serum glucose level of 428 mg/dL
increased circulating insulin level ( J:133634 )
• heterozygous progeny of the founder mouse are hyperinsulinemic
increased urine glucose level ( J:133634 )
• heterozygous progeny of the founder mouse have glucosuria

renal/urinary system
increased urine glucose level ( J:133634 )
• heterozygous progeny of the founder mouse have glucosuria




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory