immune system
• at low and intermediate doses, mice exhibit reduced leukotriene E4 ligand (LTE4)-induced ear edema compared with wild-type mice
• however, mice exhibit normal leukotriene E4 ligand (LTE4)-, leukotriene C4 (LTC4)- or leukotriene D4 (LTD4)-induced ear edema at higher doses
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