Phenotypes associated with this allele

• Allele Symbol: Arhgef15^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3812708
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef15^tm1(KOMP)Vlcg/Arhgef15^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5441623

Genotype
MGI:5441623

hm1

• Allelic Composition: Arhgef15^{tm1(KOMP)Vlcg}/Arhgef15^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10757B-C6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:188649 )

• mice exhibit delayed radial growth and sparse vasculature in the central area of the retina compared with wild-type mice

• retinal vasculature exhibit increased empty basement membrane sleeves positive for collagen

abnormal vascular regression ( J:188649 )

• mice exhibit increased vessel regression in the vascular front but not central retina compared with wild-type mice

neoplasm

neoplasm ( J:188649 )

N • mice do not exhibit abnormal growth of transplanted tumor cells

vision/eye

abnormal retina vasculature morphology ( J:188649 )

• mice exhibit delayed radial growth and sparse vasculature in the central area of the retina compared with wild-type mice

• retinal vasculature exhibit increased empty basement membrane sleeves positive for collagen

cellular

abnormal vascular regression ( J:188649 )

• mice exhibit increased vessel regression in the vascular front but not central retina compared with wild-type mice