Phenotypes associated with this allele

• Allele Symbol: Prrt1^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3812714
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prrt1^tm1(KOMP)Vlcg/Prrt1^tm1(KOMP)Vlcg	involves: C57BL/6J * C57BL/6NTac	MGI:6151121
hm2	Prrt1^tm1(KOMP)Vlcg/Prrt1^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6151120

Genotype
MGI:6151121

hm1

• Allelic Composition: Prrt1^{tm1(KOMP)Vlcg}/Prrt1^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac
• Cell Lines: 10773A-D11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:260353 )

N • mice exhibit normal anxiety-related behaviors in an elevated plus-maze and light/dark box

abnormal object recognition memory ( J:260353 )

• mice spend equal time with a novel and familiar object unlike wild-type mice

increased exploration in new environment ( J:260353 )

• moderately in an open field and elevated plus-maze

impaired spatial learning ( J:260353 )

• latency to learning in a Morris water maze is only decreased slightly compared with wild-type mice caused by a failure to use distal environmental cues

Genotype
MGI:6151120

hm2

• Allelic Composition: Prrt1^{tm1(KOMP)Vlcg}/Prrt1^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 10773A-D11

nervous system

nervous system phenotype ( J:260353 )

N • mice exhibit normal neurons dendrite complexity

reduced long-term potentiation ( J:260353 )

• impaired Schaffer-Collateral LTP using 100 Hz/1 s tetanus

• however, mice exhibit normal LTP following 10 theta-burst stimulations or pairing

abnormal miniature excitatory postsynaptic currents ( J:260353 )

• reduced amplitude but increased frequency

• however, decay kinetics are normal