Phenotypes associated with this allele

• Allele Symbol: Selenom^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3812975
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Selenom^tm1(KOMP)Vlcg/Selenom^tm1(KOMP)Vlcg	involves: C57BL/6J * C57BL/6NTac	MGI:5543600

Genotype
MGI:5543600

hm1

• Allelic Composition: Selenom^{tm1(KOMP)Vlcg}/Selenom^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac
• Cell Lines: 11537A-H3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203545 )

N • mice exhibit normal glucose tolerance and hepatic insulin signaling

N • mice fed a selenium-deficient diet exhibit normal glucose tolerance

decreased circulating corticosterone level ( J:203545 )

• during the morning trough, but not evening, period

increased circulating leptin level ( J:203545 )

♂ • in male, but not female, mice

growth/size/body

increased body weight ( J:203545 )

• beginning from 12 to 20 weeks in male and female mice

• in female, but not male, mice fed a selenium-deficient diet

obese ( J:203545 )

increased susceptibility to weight gain ( J:203545 )

• beginning from 12 to 20 weeks

adipose tissue

increased gonadal fat pad weight ( J:203545 )

• 2-fold in mice fed standard chow

• in mice fed a selenium-deficient diet

increased inguinal fat pad weight ( J:203545 )

• 2-fold in mice fed standard chow

• in mice fed a selenium-deficient diet

behavior/neurological

behavior/neurological phenotype ( J:203545 )

N • mice exhibit normal anxiety, locomotion, motor coordination, learning, memory and food intake

decreased locomotor activity ( J:203545 )

• mice fed a selenium-deficient diet travel less distance in an open field compared with control mice

nervous system

nervous system phenotype ( J:203545 )

N • mice exhibit normal brain morphology and density of PV+ interneurons