Phenotypes associated with this allele

• Allele Symbol: Ep300^Plt6
• Allele Name: Plt6
• Allele ID: MGI:3813243
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ep300^Plt6/Ep300^Plt6	involves: 129S1/Sv * C57BL/6	MGI:3813258
cx2	Ep300^Plt6/Ep300^Plt6 Mpl^tm1Wsa/Mpl^tm1Wsa	involves: 129S1/Sv * C57BL/6	MGI:3813260
cx3	Ep300^Plt6/Ep300^+ Mpl^tm1Wsa/Mpl^tm1Wsa	involves: 129S1/Sv * C57BL/6	MGI:3813262

Genotype
MGI:3813258

hm1

• Allelic Composition: Ep300^Plt6/Ep300^Plt6
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:140200 )

• about 80% of mice fail to survive to weaning

immune system

decreased leukocyte cell number ( J:140200 )

• leukocyte count is almost half that of wild-type

decreased eosinophil cell number ( J:140200 )

• eosinophil count is reduced by more than half compared to controls

decreased lymphocyte cell number ( J:140200 )

• lymphocyte count is half that of wild-type

decreased B cell number ( J:140200 )

• B cell numbers are reduced in the bone marrow, spleen, lymph nodes and in circulation

• reduction in numbers range from about one-third to one-half compared to wild-type

hematopoietic system

thrombocytosis ( J:140200 )

• mean platelet count is 1954x10⁹ compared to 1066x10⁹

decreased leukocyte cell number ( J:140200 )

• leukocyte count is almost half that of wild-type

decreased eosinophil cell number ( J:140200 )

• eosinophil count is reduced by more than half compared to controls

decreased lymphocyte cell number ( J:140200 )

• lymphocyte count is half that of wild-type

decreased B cell number ( J:140200 )

• B cell numbers are reduced in the bone marrow, spleen, lymph nodes and in circulation

• reduction in numbers range from about one-third to one-half compared to wild-type

Genotype
MGI:3813260

cx2

• Allelic Composition: Ep300^Plt6/Ep300^Plt6; Mpl^tm1Wsa/Mpl^tm1Wsa
• Genetic Background: involves: 129S1/Sv * C57BL/6

mortality/aging

postnatal lethality ( J:140200 )

• about 80% of mice fail to survive to weaning

hematopoietic system

increased megakaryocyte cell number ( J:140200 )

• megakarycoyte numbers are about 10-fold higher in the bone marrow and spleen

abnormal megakaryocyte progenitor cell morphology ( J:140200 )

• clonogenic myeloid progenitor cells are also significantly elevated by more than 3-fold in the spleen

thrombocytosis ( J:140200 )

• platelet count is increased more than 10-fold over Mpl^tm1Wsa homozygotes and more than twice as much as wild-type mice

Genotype
MGI:3813262

cx3

• Allelic Composition: Ep300^Plt6/Ep300⁺; Mpl^tm1Wsa/Mpl^tm1Wsa
• Genetic Background: involves: 129S1/Sv * C57BL/6

immune system

increased eosinophil cell number ( J:140200 )

• the eosinophil number is almost double that of Mpl^tm1Wsa homozygotes and is similar to wild-type mice

hematopoietic system

increased megakaryocyte cell number ( J:140200 )

• megakaryocyte numbers in the bone marrow and spleen are more than double what is found of wild-type mice

abnormal megakaryocyte progenitor cell morphology ( J:140200 )

• clonogenic myeloid progenitor cells are also significantly elevated by more than 3-fold in the spleen

increased eosinophil cell number ( J:140200 )

• the eosinophil number is almost double that of Mpl^tm1Wsa homozygotes and is similar to wild-type mice

abnormal platelet morphology ( J:140200 )

• platelet count is increased more than 2-fold compared to Mpl^tm1Wsa homozygotes but is about half the number found in wild-type mice