About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-cre)#Smr
transgene insertion, Sarah E Millar
MGI:3813245
Summary 12 genotypes


Genotype
MGI:5506907
cn1
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:199362 )
N
• mutants do not develop hamartomas over a period of 300 days and epidermal thickness is normal at 8 weeks of age




Genotype
MGI:5506905
cn2
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
thick epidermis stratum basale ( J:199362 )
• expanded basal cell layers
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days




Genotype
MGI:5506906
cn3
Allelic
Composition		 Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal epidermis suprabasal layer morphology ( J:199362 )
• accumulation of terminally differentiated suprabasal cells
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 131 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 131 days




Genotype
MGI:5506904
cn4
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal epidermal layer morphology ( J:199362 )
• marker analysis indicates a perturbed basal-to-suprabasal transition
thick epidermis suprabasal layer ( J:199362 )
• expanded suprabasal layer as indicated by an increase in Keratin 10-postive cells
thick epidermis ( J:199362 )
• increase in the number of epidermal cell layers at 8 weeks of age
skin lesions ( J:199362 )
• progressive development of multiple dermal lesions after weaning
thick skin ( J:199362 )
• at 8 weeks of age
increased skin hamartoma incidence ( J:199362 )
• multiple cutaneous hamartomas are seen all over the body within 12 weeks of age
• median onset of disease is 62 days
• mice treated with BKM120, a pan-class I PI3K inhibitor, beginning at 3 weeks of age, do not develop PTEN hamartoma tumor syndrome skin lesions; removal of BKM120 results in development of lesions, indicating that continuous treatment is required
• mice with advanced multiple skin hamartomas treated with BKM120 show improved skin conditions
increased skin papilloma incidence ( J:199362 )
• papillomatous lesions around the facial orifices, ears, and paws, with most associated with hyperkeratosis

neoplasm
increased skin hamartoma incidence ( J:199362 )
• multiple cutaneous hamartomas are seen all over the body within 12 weeks of age
• median onset of disease is 62 days
• mice treated with BKM120, a pan-class I PI3K inhibitor, beginning at 3 weeks of age, do not develop PTEN hamartoma tumor syndrome skin lesions; removal of BKM120 results in development of lesions, indicating that continuous treatment is required
• mice with advanced multiple skin hamartomas treated with BKM120 show improved skin conditions
increased skin papilloma incidence ( J:199362 )
• papillomatous lesions around the facial orifices, ears, and paws, with most associated with hyperkeratosis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Cowden syndrome DOID:6457 OMIM:PS158350
 J:199362




Genotype
MGI:4889120
cn5
Allelic
Composition		 Pygo2tm1.1Xdai/Pygo2tm1.2Xdai
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Xdai mutation (0 available); any Pygo2 mutation (24 available)
Pygo2tm1.2Xdai mutation (0 available); any Pygo2 mutation (24 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:163218 )
• mammary progenitor cells exhibit impaired expansion compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal mammary gland development ( J:163218 )
• at 3 weeks, mice lack terminal end buds compared with wild-type mice
• at 6 weeks, ductal elongation is delayed compared to in wild-type mice
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal branching of the mammary ductal tree ( J:163218 )
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
abnormal mammary gland embryonic development ( J:163218 )
• in some newborn mice exhibit impaired mammary gland development compared with wild-type mice
abnormal mammary gland growth during lactation ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice
abnormal mammary gland growth during pregnancy ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

integument
decreased mammary gland epithelial cell proliferation ( J:163218 )
• mammary progenitor cells exhibit impaired expansion compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal mammary gland development ( J:163218 )
• at 3 weeks, mice lack terminal end buds compared with wild-type mice
• at 6 weeks, ductal elongation is delayed compared to in wild-type mice
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal branching of the mammary ductal tree ( J:163218 )
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
abnormal mammary gland embryonic development ( J:163218 )
• in some newborn mice exhibit impaired mammary gland development compared with wild-type mice
abnormal mammary gland growth during lactation ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice
abnormal mammary gland growth during pregnancy ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

reproductive system
abnormal mammary gland growth during pregnancy ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

cellular
decreased mammary gland epithelial cell proliferation ( J:163218 )
• mammary progenitor cells exhibit impaired expansion compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal




Genotype
MGI:5905989
cn6
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tongue morphology ( J:242196 )
• flattened surface
abnormal filiform papillae morphology ( J:242196 )
• defective formation of tongue filiform papillae and the tongue barrier

growth/size/body
abnormal tongue morphology ( J:242196 )
• flattened surface
abnormal filiform papillae morphology ( J:242196 )
• defective formation of tongue filiform papillae and the tongue barrier

cellular
decreased cell proliferation ( J:242196 )
• decreased sweat duct basal cell proliferation

digestive/alimentary system
abnormal tongue morphology ( J:242196 )
• flattened surface
abnormal filiform papillae morphology ( J:242196 )
• defective formation of tongue filiform papillae and the tongue barrier




Genotype
MGI:3813526
cn7
Allelic
Composition		 Ptentm1Hwu/Pten+
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:138927 )
• mice exhibit decreased survival compared to wild type mice

neoplasm
increased mammary gland tumor incidence ( J:138927 )
• 36% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:138927 )
• 36% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis

integument
increased mammary gland tumor incidence ( J:138927 )
• 36% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis




Genotype
MGI:3813525
cn8
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:138927 )
• 40% of mice survive weaning if littermate competition is removed and the weaning period is extended
premature death ( J:138927 )
• mice that survive weaning do not live beyond 250 days
• however, survival can be increased by treatment with rapamycin
postnatal lethality, incomplete penetrance ( J:138927 )
• mice die rapidly in the first few days of life
• however, lifespan can be increased if littermate competition is removed and the weaning period is extended

neoplasm
increased thyroid tumor incidence ( J:138927 )
• 12% of mice develop thyroid tumors with a follicular aspect
increased mammary gland tumor incidence ( J:138927 )
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
increased skin tumor incidence ( J:138927 )
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
increased skin papilloma incidence ( J:138927 )
• mice develop papules around the nose, mouth and eyes

endocrine/exocrine glands
enlarged thyroid gland ( J:138927 )
• 56% of mice develop multinodular goiters
increased thyroid tumor incidence ( J:138927 )
• 12% of mice develop thyroid tumors with a follicular aspect
abnormal nipple morphology ( J:138927 )
• in 80% of mice
increased mammary gland tumor incidence ( J:138927 )
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis

integument
abnormal nipple morphology ( J:138927 )
• in 80% of mice
increased mammary gland tumor incidence ( J:138927 )
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
abnormal hair shaft morphology ( J:138927 )
• at 11 days, the hair shafts have a disheveled appearance unlike in heterozygous mice
enlarged hair follicles ( J:138927 )
• hair follicles are increased in size compared to in wild type mice
abnormal vibrissa follicle morphology ( J:138927 )
• facial and periauricular lesions involve hyperproliferation of the outer root sheath in the vibrissae
hyperkeratosis ( J:138927 )
• papillomatous lesions of the skin exhibit hyperkeratosis and acanthosis through the face and body skin
acanthosis ( J:138927 )
• papillomatous lesions of the skin exhibit hyperkeratosis and acanthosis through the face and body skin
flaky skin ( J:138927 )
• at 6 days of age
skin lesions ( J:138927 )
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
• facial and periauricular lesions involve hyperproliferation of the outer root sheath and vibrissae
• acral extremities areas exhibit verrucous and hyperkeratotic lesions also seen in the punctuate palmoplantar keratosis of the paws
• mice exhibit palmoplantar keratoses, acral keratosis and oral papules
• cutaneous lesions contain trichilemmomas
• however, rapamycin treatment reverses and prevents lesion formation
wrinkled skin ( J:138927 )
• at 6 days of age
increased skin tumor incidence ( J:138927 )
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
increased skin papilloma incidence ( J:138927 )
• mice develop papules around the nose, mouth and eyes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Cowden syndrome DOID:6457 OMIM:PS158350
 J:138927




Genotype
MGI:5905987
cn9
Allelic
Composition		 Wnt10atm1Smr/Wnt10atm1Smr
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)#Smr mutation (0 available)
Wnt10atm1Smr mutation (0 available); any Wnt10a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:242196 )
N
• bone density is normal
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars

growth/size/body
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars

craniofacial
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars




Genotype
MGI:3813247
cn10
Allelic
Composition		 Dlx3tm2Mso/Dlx3tm3Mso
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx3tm2Mso mutation (0 available); any Dlx3 mutation (11 available)
Dlx3tm3Mso mutation (0 available); any Dlx3 mutation (11 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:140203 )
abnormal postnatal growth ( J:140203 )

endocrine/exocrine glands
enlarged sebaceous gland ( J:140203 )
• at P15 and P18

integument
enlarged sebaceous gland ( J:140203 )
• at P15 and P18
abnormal hair shaft morphology ( J:140203 )
• at P12, mice exhibit defects in the hair shaft
abnormal hair follicle morphology ( J:140203 )
• beginning at P5, mice exhibit abnormal hair follicles
• hair follicles undergo epidermalization unlike in wild-type mice
• at P12, mice exhibit defects in the inner root sheath with continued proliferation of outer root sheath cells in catagen and telogen unlike in wild-type mice
abnormal hair follicle development ( J:140203 )
• at P9, follicles have not develop hair bulbs and exhibit abnormal undifferentiated shafts with no keratinized medulla unlike in wild-type mice
• at P18, mice fail to exhibit upward movement of the hair shaft and formation of the club structure in the upper hair bulb as in wild-type mice
accelerated hair follicle regression ( J:140203 )
• by telogen phase P20, hair follicles undergo regression and fail to re-initiate the hair cycle as in wild type mice
increased hair follicle cell proliferation ( J:140203 )
• at P15, P18 and P26, proliferation of hair follicle cells is increased compared to in wild-type mice
thick dermal layer ( J:140203 )
• the dermis is thickened and hypercellular compared to in wild-type mice
abnormal epidermal layer morphology ( J:140203 )
• at P15 and P18, utricles develop in the epidermis unlike in wild-type mice




Genotype
MGI:5905990
cn11
Allelic
Composition		 Tg(tetO-Dkk1)1Smr/0
Tg(KRT14-Kremen1)1Smr/0
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tongue morphology ( J:242196 )
• flattened surface

digestive/alimentary system
abnormal tongue morphology ( J:242196 )
• flattened surface

endocrine/exocrine glands
abnormal sweat gland morphology ( J:242196 )
• regression of sweat glands when treated with doxycycline at P20
hypohidrosis ( J:242196 )
• when treated with doxycycline at P20

growth/size/body
abnormal tongue morphology ( J:242196 )
• flattened surface

integument
abnormal sweat gland morphology ( J:242196 )
• regression of sweat glands when treated with doxycycline at P20
hypohidrosis ( J:242196 )
• when treated with doxycycline at P20




Genotype
MGI:3813246
cn12
Allelic
Composition		 Dlx3tm3Mso/Dlx3tm3Mso
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx3tm3Mso mutation (0 available); any Dlx3 mutation (11 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:140203 )
abnormal postnatal growth ( J:140203 )

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory