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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-cre)#Smr
transgene insertion, Sarah E Millar
MGI:3813245
Summary 12 genotypes


Genotype
MGI:5506907
cn1
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:199362 )
N
• mutants do not develop hamartomas over a period of 300 days and epidermal thickness is normal at 8 weeks of age




Genotype
MGI:5506905
cn2
Allelic
Composition		 Pik3catm1Jjz/Pik3catm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3catm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3catm1Jjz mutation (1 available); any Pik3ca mutation (66 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
thick epidermis stratum basale ( J:199362 )
• expanded basal cell layers
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 121 days




Genotype
MGI:5506906
cn3
Allelic
Composition		 Pik3cbtm1Jjz/Pik3cbtm1Jjz
Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Pik3cbtm1Jjz Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1Jjz mutation (1 available); any Pik3cb mutation (152 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal epidermis suprabasal layer morphology ( J:199362 )
• accumulation of terminally differentiated suprabasal cells
skin lesions ( J:199362 )
• development of skin lesions is delayed and severity is reduced compared to single Pten mutants
thick skin ( J:199362 )
• skin is thickened at 8 weeks of age, but to a lesser extent than in single Pten mutants
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 131 days

neoplasm
increased skin hamartoma incidence ( J:199362 )
• develop skin hamartomas with a median latency of 131 days




Genotype
MGI:5506904
cn4
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 FVB.Cg-Ptentm1Hwu Tg(KRT14-cre)#Smr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal epidermal layer morphology ( J:199362 )
• marker analysis indicates a perturbed basal-to-suprabasal transition
thick epidermis suprabasal layer ( J:199362 )
• expanded suprabasal layer as indicated by an increase in Keratin 10-postive cells
thick epidermis ( J:199362 )
• increase in the number of epidermal cell layers at 8 weeks of age
skin lesions ( J:199362 )
• progressive development of multiple dermal lesions after weaning
thick skin ( J:199362 )
• at 8 weeks of age
increased skin hamartoma incidence ( J:199362 )
• multiple cutaneous hamartomas are seen all over the body within 12 weeks of age
• median onset of disease is 62 days
• mice treated with BKM120, a pan-class I PI3K inhibitor, beginning at 3 weeks of age, do not develop PTEN hamartoma tumor syndrome skin lesions; removal of BKM120 results in development of lesions, indicating that continuous treatment is required
• mice with advanced multiple skin hamartomas treated with BKM120 show improved skin conditions
increased skin papilloma incidence ( J:199362 )
• papillomatous lesions around the facial orifices, ears, and paws, with most associated with hyperkeratosis

neoplasm
increased skin hamartoma incidence ( J:199362 )
• multiple cutaneous hamartomas are seen all over the body within 12 weeks of age
• median onset of disease is 62 days
• mice treated with BKM120, a pan-class I PI3K inhibitor, beginning at 3 weeks of age, do not develop PTEN hamartoma tumor syndrome skin lesions; removal of BKM120 results in development of lesions, indicating that continuous treatment is required
• mice with advanced multiple skin hamartomas treated with BKM120 show improved skin conditions
increased skin papilloma incidence ( J:199362 )
• papillomatous lesions around the facial orifices, ears, and paws, with most associated with hyperkeratosis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Cowden syndrome DOID:6457 OMIM:PS158350
 J:199362




Genotype
MGI:4889120
cn5
Allelic
Composition		 Pygo2tm1.1Xdai/Pygo2tm1.2Xdai
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Xdai mutation (0 available); any Pygo2 mutation (24 available)
Pygo2tm1.2Xdai mutation (0 available); any Pygo2 mutation (24 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland epithelial cell proliferation ( J:163218 )
• mammary progenitor cells exhibit impaired expansion compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal mammary gland development ( J:163218 )
• at 3 weeks, mice lack terminal end buds compared with wild-type mice
• at 6 weeks, ductal elongation is delayed compared to in wild-type mice
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal branching of the mammary ductal tree ( J:163218 )
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
abnormal mammary gland embryonic development ( J:163218 )
• in some newborn mice exhibit impaired mammary gland development compared with wild-type mice
abnormal mammary gland growth during lactation ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice
abnormal mammary gland growth during pregnancy ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

integument
decreased mammary gland epithelial cell proliferation ( J:163218 )
• mammary progenitor cells exhibit impaired expansion compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal mammary gland development ( J:163218 )
• at 3 weeks, mice lack terminal end buds compared with wild-type mice
• at 6 weeks, ductal elongation is delayed compared to in wild-type mice
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal
abnormal branching of the mammary ductal tree ( J:163218 )
• at 9 weeks, mammary glands exhibit fewer branches and lateral buds compared to in wild-type mice
abnormal mammary gland embryonic development ( J:163218 )
• in some newborn mice exhibit impaired mammary gland development compared with wild-type mice
abnormal mammary gland growth during lactation ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice
abnormal mammary gland growth during pregnancy ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

reproductive system
abnormal mammary gland growth during pregnancy ( J:163218 )
• during pregnancy and lactation, mice exhibit reduced alveolar formation compared with wild-type mice

cellular
decreased mammary gland epithelial cell proliferation ( J:163218 )
• mammary progenitor cells exhibit impaired expansion compared to in wild-type mice
• however, mammary progenitor cell differentiation is normal




Genotype
MGI:5905989
cn6
Allelic
Composition		 Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tongue morphology ( J:242196 )
• flattened surface
abnormal filiform papillae morphology ( J:242196 )
• defective formation of tongue filiform papillae and the tongue barrier

growth/size/body
abnormal tongue morphology ( J:242196 )
• flattened surface
abnormal filiform papillae morphology ( J:242196 )
• defective formation of tongue filiform papillae and the tongue barrier

cellular
decreased cell proliferation ( J:242196 )
• decreased sweat duct basal cell proliferation

digestive/alimentary system
abnormal tongue morphology ( J:242196 )
• flattened surface
abnormal filiform papillae morphology ( J:242196 )
• defective formation of tongue filiform papillae and the tongue barrier




Genotype
MGI:3813526
cn7
Allelic
Composition		 Ptentm1Hwu/Pten+
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:138927 )
• mice exhibit decreased survival compared to wild type mice

neoplasm
increased mammary gland tumor incidence ( J:138927 )
• 36% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:138927 )
• 36% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis

integument
increased mammary gland tumor incidence ( J:138927 )
• 36% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis




Genotype
MGI:3813525
cn8
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:138927 )
• 40% of mice survive weaning if littermate competition is removed and the weaning period is extended
premature death ( J:138927 )
• mice that survive weaning do not live beyond 250 days
• however, survival can be increased by treatment with rapamycin
postnatal lethality, incomplete penetrance ( J:138927 )
• mice die rapidly in the first few days of life
• however, lifespan can be increased if littermate competition is removed and the weaning period is extended

neoplasm
increased thyroid tumor incidence ( J:138927 )
• 12% of mice develop thyroid tumors with a follicular aspect
increased mammary gland tumor incidence ( J:138927 )
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
increased skin tumor incidence ( J:138927 )
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
increased skin papilloma incidence ( J:138927 )
• mice develop papules around the nose, mouth and eyes

endocrine/exocrine glands
enlarged thyroid gland ( J:138927 )
• 56% of mice develop multinodular goiters
increased thyroid tumor incidence ( J:138927 )
• 12% of mice develop thyroid tumors with a follicular aspect
abnormal nipple morphology ( J:138927 )
• in 80% of mice
increased mammary gland tumor incidence ( J:138927 )
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis

integument
abnormal nipple morphology ( J:138927 )
• in 80% of mice
increased mammary gland tumor incidence ( J:138927 )
• 11% of mice exhibit thoracic and abdominal/inguinal mammary gland tumors
• mammary gland tumors exhibit prominent intraluminal and ductal proliferation
• mammary gland tumors ranged from fibroadenomas to adenocarcinomas and ductal carcinomas with dense hyaline collagen or dense fibrosis
abnormal hair shaft morphology ( J:138927 )
• at 11 days, the hair shafts have a disheveled appearance unlike in heterozygous mice
enlarged hair follicles ( J:138927 )
• hair follicles are increased in size compared to in wild type mice
abnormal vibrissa follicle morphology ( J:138927 )
• facial and periauricular lesions involve hyperproliferation of the outer root sheath in the vibrissae
hyperkeratosis ( J:138927 )
• papillomatous lesions of the skin exhibit hyperkeratosis and acanthosis through the face and body skin
acanthosis ( J:138927 )
• papillomatous lesions of the skin exhibit hyperkeratosis and acanthosis through the face and body skin
flaky skin ( J:138927 )
• at 6 days of age
skin lesions ( J:138927 )
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
• facial and periauricular lesions involve hyperproliferation of the outer root sheath and vibrissae
• acral extremities areas exhibit verrucous and hyperkeratotic lesions also seen in the punctuate palmoplantar keratosis of the paws
• mice exhibit palmoplantar keratoses, acral keratosis and oral papules
• cutaneous lesions contain trichilemmomas
• however, rapamycin treatment reverses and prevents lesion formation
wrinkled skin ( J:138927 )
• at 6 days of age
increased skin tumor incidence ( J:138927 )
• mice develop multiple hyperproliferative skin lesions that range from mucocutaneous lesions to tumor formation
increased skin papilloma incidence ( J:138927 )
• mice develop papules around the nose, mouth and eyes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Cowden syndrome DOID:6457 OMIM:PS158350
 J:138927




Genotype
MGI:5905987
cn9
Allelic
Composition		 Wnt10atm1Smr/Wnt10atm1Smr
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)#Smr mutation (0 available)
Wnt10atm1Smr mutation (0 available); any Wnt10a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:242196 )
N
• bone density is normal
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars

growth/size/body
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars

craniofacial
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars




Genotype
MGI:3813247
cn10
Allelic
Composition		 Dlx3tm2Mso/Dlx3tm3Mso
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx3tm2Mso mutation (0 available); any Dlx3 mutation (11 available)
Dlx3tm3Mso mutation (0 available); any Dlx3 mutation (11 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:140203 )
abnormal postnatal growth ( J:140203 )

endocrine/exocrine glands
enlarged sebaceous gland ( J:140203 )
• at P15 and P18

integument
enlarged sebaceous gland ( J:140203 )
• at P15 and P18
abnormal hair shaft morphology ( J:140203 )
• at P12, mice exhibit defects in the hair shaft
abnormal hair follicle morphology ( J:140203 )
• beginning at P5, mice exhibit abnormal hair follicles
• hair follicles undergo epidermalization unlike in wild-type mice
• at P12, mice exhibit defects in the inner root sheath with continued proliferation of outer root sheath cells in catagen and telogen unlike in wild-type mice
abnormal hair follicle development ( J:140203 )
• at P9, follicles have not develop hair bulbs and exhibit abnormal undifferentiated shafts with no keratinized medulla unlike in wild-type mice
• at P18, mice fail to exhibit upward movement of the hair shaft and formation of the club structure in the upper hair bulb as in wild-type mice
accelerated hair follicle regression ( J:140203 )
• by telogen phase P20, hair follicles undergo regression and fail to re-initiate the hair cycle as in wild type mice
increased hair follicle cell proliferation ( J:140203 )
• at P15, P18 and P26, proliferation of hair follicle cells is increased compared to in wild-type mice
thick dermal layer ( J:140203 )
• the dermis is thickened and hypercellular compared to in wild-type mice
abnormal epidermal layer morphology ( J:140203 )
• at P15 and P18, utricles develop in the epidermis unlike in wild-type mice




Genotype
MGI:5905990
cn11
Allelic
Composition		 Tg(tetO-Dkk1)1Smr/0
Tg(KRT14-Kremen1)1Smr/0
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tongue morphology ( J:242196 )
• flattened surface

digestive/alimentary system
abnormal tongue morphology ( J:242196 )
• flattened surface

endocrine/exocrine glands
abnormal sweat gland morphology ( J:242196 )
• regression of sweat glands when treated with doxycycline at P20
hypohidrosis ( J:242196 )
• when treated with doxycycline at P20

growth/size/body
abnormal tongue morphology ( J:242196 )
• flattened surface

integument
abnormal sweat gland morphology ( J:242196 )
• regression of sweat glands when treated with doxycycline at P20
hypohidrosis ( J:242196 )
• when treated with doxycycline at P20




Genotype
MGI:3813246
cn12
Allelic
Composition		 Dlx3tm3Mso/Dlx3tm3Mso
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx3tm3Mso mutation (0 available); any Dlx3 mutation (11 available)
Tg(KRT14-cre)#Smr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
weight loss ( J:140203 )
abnormal postnatal growth ( J:140203 )

integument




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory