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Allele Symbol Allele Name Allele ID |
Tg(DMPK/tetO-EGFP/DMPK)5-313Masm transgene insertion 5-313, Mani S Mahadevan MGI:3813454 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by 3 weeks of treatment with doxycycline, mice exhibit myotonia
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• at 2 weeks post treatment with doxycycline, mice exhibit a less dramatic increase in PR intervals than in Tg(DMPK/tetO-GFP/DMPK)5-313Masm mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• within 2 weeks of treatment with doxycycline, mice develop myotonia
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• within 2 weeks of treatment with doxycycline, mice develop progressive heart block
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth exhibit muscle fiber atrophy
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• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth exhibit muscles with a greater degree of fiber size variability
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• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth exhibit muscles with an increase in centrally nucleated fibers
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• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth exhibit an increase in myotonic dystrophy disease severity compared to mice treated with doxycycline starting at 2 months of age for a total of 8 weeks, showing a PR interval increase of 46.75% compared to 17.93% in the adult-induced mice, worse myotonia score, and more severe loss of grip strength, although a slightly milder muscle histology
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• following treatment with doxycycline, mice exhibit myotonia
(J:131302)
• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth exhibit weak and intermittent myotonia at 2 weeks of age that increases in severity by 4 weeks of age
(J:207560)
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• following treatment with doxycycline, mice develop progressive heart block
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• following treatment with doxycycline
(J:131302)
• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth exhibit a lengthened PR interval by 4 and 6 weeks of age, indicating cardiac conduction defects
(J:207560)
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• mice treated with doxycycline throughout gestation, birth, and rearing up to 6 weeks after birth have weaker forelimb grip strength at 4 and 6 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| myotonic dystrophy type 1 | DOID:11722 |
OMIM:160900 |
J:207560 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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