Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-MAPT*)1Avil
• Allele Name: transgene insertion 1, J Avila
• Allele ID: MGI:3813500
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Thy1-MAPT*)1Avil/Tg(Thy1-MAPT*)1Avil	involves: C57BL/6 * CBA	MGI:5529794
tg2	Tg(Thy1-MAPT*)1Avil/0	involves: C57BL/6 * CBA	MGI:3813502

Genotype
MGI:5529794

tg1

• Allelic Composition: Tg(Thy1-MAPT*)1Avil/Tg(Thy1-MAPT*)1Avil
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:201700 )

• 10-30% of mice show epileptic seizures at all ages analyzed

increased susceptibility to pharmacologically induced seizures ( J:201700 )

• mice show increased sensitivity to the chemoconvulsant agent pentylenetetrazol, showing reduced seizure latency, increased seizure length and increased lethality compared to controls

myoclonus ( J:201700 )

• 70% of mutants exhibit spontaneous myoclonus at 5.5 months of age

• mutants display myoclonic jerks and periods of immobility followed by a seizure

tonic-clonic seizures ( J:201700 )

• 10% of mutants exhibit spontaneous generalized tonic-clonic seizures (generalized low-frequency polyspike-wave discharges) at 14 months of age

nonconvulsive seizures ( J:201700 )

• mutants show nonconvulsive spontaneous seizures with EEG correlates corresponding to epileptic rhythmic, spindle-shaped discharges

tau protein deposits ( J:201700 )

• phosphorylated-tau aggregates are seen in the brain

gliosis ( J:201700 )

• reactive gliosis in the hippocampus

microgliosis ( J:201700 )

• activated microglia in the brain

astrocytosis ( J:201700 )

• reactive astrocytes in the brain

behavior/neurological

seizures ( J:201700 )

• 10-30% of mice show epileptic seizures at all ages analyzed

increased susceptibility to pharmacologically induced seizures ( J:201700 )

• mice show increased sensitivity to the chemoconvulsant agent pentylenetetrazol, showing reduced seizure latency, increased seizure length and increased lethality compared to controls

myoclonus ( J:201700 )

• 70% of mutants exhibit spontaneous myoclonus at 5.5 months of age

• mutants display myoclonic jerks and periods of immobility followed by a seizure

tonic-clonic seizures ( J:201700 )

• 10% of mutants exhibit spontaneous generalized tonic-clonic seizures (generalized low-frequency polyspike-wave discharges) at 14 months of age

nonconvulsive seizures ( J:201700 )

• mutants show nonconvulsive spontaneous seizures with EEG correlates corresponding to epileptic rhythmic, spindle-shaped discharges

hematopoietic system

microgliosis ( J:201700 )

• activated microglia in the brain

immune system

microgliosis ( J:201700 )

• activated microglia in the brain

muscle

myoclonus ( J:201700 )

• 70% of mutants exhibit spontaneous myoclonus at 5.5 months of age

• mutants display myoclonic jerks and periods of immobility followed by a seizure

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
frontotemporal dementia		DOID:9255	OMIM:600274	J:201700

Genotype
MGI:3813502

tg2

• Allelic Composition: Tg(Thy1-MAPT*)1Avil/0
• Genetic Background: involves: C57BL/6 * CBA

nervous system

abnormal dentate gyrus morphology ( J:182782 )

• 4 month old mutants exhibit a decrease in the volume of the ventral dentate gyrus but not of the dorsal dentate gyrus

• mutants exhibit an increase in neuronal cell death in both the dorsal and ventral dentate gyrus

• marker analysis indicates a decrease in the number of immature neuronal precursors in both the dorsal and ventral dentate gyrus

abnormal hippocampus granule cell layer ( J:182782 )

• 4 month old mutants exhibit a decrease in the number of mature granule cells in the ventral dentate gyrus but not in the dorsal dentate gyrus

• mutants exhibit a decrease in the number of PH3+ cells in the ventral dentate gyrus, indicating decreased cell proliferation of granule neuron precursors in this region

abnormal innervation ( J:182782 )

• increase in GABAergic innervation in the molecular layer of the dorsal dentate gyrus

abnormal neuron morphology ( J:73872 )

• neurons exhibit a pretangle appearance with filaments of MAPT and increased lysosomal abnormalities

hippocampal neuron degeneration ( J:182782 )

• expression of hyperphosphorylated tau is greater in immature neurons of the ventral dentate gyrus, indicating premature neuronal damage

behavior/neurological

behavioral despair ( J:182782 )

• in the Porsolt test, mutants are immobile longer than wild-type animals and spend less time climbing, indicating despair and possibly depression