All Phenotypes Spast<M1Gri> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Spast^M1Gri
mutation 1, Andrew J Grierson
MGI:3813522

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spast^M1Gri/Spast^M1Gri	B6.C-Spast^M1Gri	MGI:3847312
ht2	Spast^M1Gri/Spast⁺	B6.C-Spast^M1Gri	MGI:3847313

Allelic Composition	Spast^M1Gri/Spast^M1Gri
Genetic Background	B6.C-Spast^M1Gri

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spast^M1Gri mutation (0 available); any Spast mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:148877 )

• mice exhibit axonal swelling containing stalled cargoes in cortical neurons unlike in wild-type mice

• however, axonal branching is normal

abnormal axonal transport ( J:148877 )

• anterograde axonal transport of mitochondria is reduced 25% and anterograde of APP-marked membrane bound organelles is decreased compared to in wild-type mice

behavior/neurological

abnormal gait ( J:148877 )

• at 7 and 12 months, mice exhibit increase in the hind limb base of support compared with wild-type mice

• however, mice exhibit normal muscle strength and motor coordination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spastic paraplegia 4		DOID:0110792	OMIM:182601	J:148877

Allelic Composition	Spast^M1Gri/Spast⁺
Genetic Background	B6.C-Spast^M1Gri