Phenotypes associated with this allele

• Allele Symbol: Sync^tm1.1Ked
• Allele Name: targeted mutation 1.1, Kay E Davies
• Allele ID: MGI:3813569
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sync^tm1.1Ked/Sync^tm1.1Ked	involves: 129/Sv * C57BL/6	MGI:3813615

Genotype
MGI:3813615

hm1

• Allelic Composition: Sync^tm1.1Ked/Sync^tm1.1Ked
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:138552 )

N • no morphological or histological abnormalities observed

impaired skeletal muscle contractility ( J:138552 )

• a 27.9% decrease in maximum force generation is seen during contractile testing of the extensor digitorum longus muscle

• force generation by the soleus muscle is normal

homeostasis/metabolism

increased circulating creatine kinase level ( J:138552 )

• significantly greater elevation in serum creatine kinase after running relative to controls