Phenotypes associated with this allele

• Allele Symbol: Tg(SV40-Igk4C8)L1Hon
• Allele Name: transgene insertion L1, Tasuku Honjo
• Allele ID: MGI:3813630
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(SV40-Igh-64C8)H3Hon/0 Tg(SV40-Igk4C8)L1Hon/0	involves: C57BL/6	MGI:3813631

Genotype
MGI:3813631

cx1

• Allelic Composition: Tg(SV40-Igh-64C8)H3Hon/0; Tg(SV40-Igk4C8)L1Hon/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell clonal deletion ( J:139864 )

• idiotype positive Ly-1 B cells escape clonal deletion

hemolytic anemia ( J:139864 )

• about 5% of mice develop anemia with an enormous accumulation of agglutinated erythrocytes

• tolerant mice become anemic following injection of LPS

decreased hematocrit ( J:139864 )

• inversely correlated with autoantibody levels

• mice fall within 3 categories; those with anemia (hematocrit less than 30%, 5% of mice), those that are intermediate (hematocrit between 30% and 40%, 44% of mice) and those that are tolerant (hematocrit above 40%, 51% of mice)

abnormal B cell number ( J:139864 )

• general decrease in idiotype positive B cells and large decrease in the ratio of B cells to pre B cells in the spleen and lymph node

• the degree of deletion of idiotype positive B cells varies among individuals

• remaining B cells are anergized

• no difference in B cell number or the ratio of B cells to pre B cells is seen in the bone marrow

increased erythrocyte clearance ( J:139864 )

• red blood cell half life is decreased in mice in the intermediate group

immune system

abnormal B cell clonal deletion ( J:139864 )

• idiotype positive Ly-1 B cells escape clonal deletion

abnormal B cell number ( J:139864 )

• general decrease in idiotype positive B cells and large decrease in the ratio of B cells to pre B cells in the spleen and lymph node

• the degree of deletion of idiotype positive B cells varies among individuals

• remaining B cells are anergized

• no difference in B cell number or the ratio of B cells to pre B cells is seen in the bone marrow

increased anti-erythrocyte antigen antibody level ( J:139864 )

• considerable amounts of autoantibody are found associated with erythrocytes

• the amount of autoantibody present varies over a 2-log range

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autoimmune hemolytic anemia		DOID:718	OMIM:205700	J:139864