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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-cat,-TBX3)1Vmc
transgene insertion 1, Vincent M Christoffels
MGI:3813723
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Myh6-cre)2182Mds/0 		involves: FVB/N MGI:5314604
cn2
 		Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Nppa-cre)3Vmc/0 		Not Specified MGI:3813725
cn3
 		Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Nppa-cre)4Vmc/0 		Not Specified MGI:3813727
cn4
 		Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Nppa-cre)m-3+4Vmc/0 		Not Specified MGI:5314605


Genotype
MGI:5314604
cn1
Allelic
Composition		 Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cat,-TBX3)1Vmc mutation (0 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
myocardium hypoplasia ( J:181526 )
• mice exhibit hypoplastic chamber walls with reduced cellular proliferation in the ventricular walls compared to in control mice
abnormal heart development ( J:181526 )
• mice exhibit a subendocardial space near the atrioventricular cushions filled with mesenchymal cells unlike in control mice
• mice exhibit abnormal cardiac jelly and cushion formation in chamber myocardium compared with control mice

muscle
myocardium hypoplasia ( J:181526 )
• mice exhibit hypoplastic chamber walls with reduced cellular proliferation in the ventricular walls compared to in control mice




Genotype
MGI:3813725
cn2
Allelic
Composition		 Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Nppa-cre)3Vmc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:121230 )
• 90% of intact right and 40% of intact left atria free from sinoatrial node and internodal tract myocytes show ectopic spontaneous electrical activity indicating ectopic pacemaker activity
ventricular premature beat ( J:121230 )
• examination of RR intervals reveals short periods of 1 - 3 irregular, premature beats between periods of normal activity




Genotype
MGI:3813727
cn3
Allelic
Composition		 Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Nppa-cre)4Vmc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
dilated heart atrium ( J:121230 )
• develop dilation of the atria several weeks after birth
cardiac fibrosis ( J:121230 )
• develop atrial fibrosis several weeks after birth
abnormal cardiovascular system physiology ( J:121230 )
• 7 of 15 isolated right atrial myocytes showed pacemaker activity which was not seen in any myocytes from controls




Genotype
MGI:5314605
cn4
Allelic
Composition		 Tg(CAG-cat,-TBX3)1Vmc/0
Tg(Nppa-cre)m-3+4Vmc/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal subendocardium layer morphology ( J:181526 )
• at E17.5, mice exhibit a thick sub-endocardial layer of cells in the atria unlike in control mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory