Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rap1atm1Laaq targeted mutation 1, Lawrence A Quilliam MGI:3813936 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following treatment with Matrigel impregnated with heparin and Fgf2, mice exhibit little to no angiogenic response unlike in similarly treated wild-type mice
• following treatment with Fgf2, aortic rings exhibit minimal tube outgrowth or branching compared to similarly treated wild-type aortic rings
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: some mice die before E9.5 on a congenic C57BL/6 background
• however, mice on a mixed background are born in normal Mendelian ratios
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| N |
• development of B cell, T cell, macrophage and granulocyte is normal
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• basal and chemokine stimulated migration of T cells, B cells, myeloid cells, and bone marrow derived T cells, B cells and macrophages is decreased compared to wild-type cells
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• neutrophils exhibit a reduced oxidative burst following stimulation with fMLP compared to similarly treated wild-type cells
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• macrophages exhibit reduced integrin-dependent adhesion and increased haptotaxis, migration and phagocytosis compared to wild-type mice
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• basal and chemokine stimulated migration of T cells, B cells, myeloid cells, and bone marrow derived T cells, B cells and macrophages is decreased compared to wild-type cells
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• basal and chemokine stimulated migration of T cells, B cells, myeloid cells, and bone marrow derived T cells, B cells and macrophages is decreased compared to wild-type cells
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• neutrophils exhibit a reduced oxidative burst following stimulation with fMLP compared to similarly treated wild-type cells
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• macrophages exhibit reduced integrin-dependent adhesion and increased haptotaxis, migration and phagocytosis compared to wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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