About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rap1atm1Laaq
targeted mutation 1, Lawrence A Quilliam
MGI:3813936
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rap1atm1Laaq/Rap1atm1Laaq B6.Cg-Rap1atm1Laaq MGI:3814189
hm2
Rap1atm1Laaq/Rap1atm1Laaq either: B6.Cg-Rap1atm1Laaq or (involves: C57BL/6) MGI:3814190


Genotype
MGI:3814189
hm1
Allelic
Composition
Rap1atm1Laaq/Rap1atm1Laaq
Genetic
Background
B6.Cg-Rap1atm1Laaq
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rap1atm1Laaq mutation (0 available); any Rap1a mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• following treatment with Matrigel impregnated with heparin and Fgf2, mice exhibit little to no angiogenic response unlike in similarly treated wild-type mice
• following treatment with Fgf2, aortic rings exhibit minimal tube outgrowth or branching compared to similarly treated wild-type aortic rings




Genotype
MGI:3814190
hm2
Allelic
Composition
Rap1atm1Laaq/Rap1atm1Laaq
Genetic
Background
either: B6.Cg-Rap1atm1Laaq or (involves: C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rap1atm1Laaq mutation (0 available); any Rap1a mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: some mice die before E9.5 on a congenic C57BL/6 background
• however, mice on a mixed background are born in normal Mendelian ratios

immune system
N
• development of B cell, T cell, macrophage and granulocyte is normal
• basal and chemokine stimulated migration of T cells, B cells, myeloid cells, and bone marrow derived T cells, B cells and macrophages is decreased compared to wild-type cells
• neutrophils exhibit a reduced oxidative burst following stimulation with fMLP compared to similarly treated wild-type cells
• macrophages exhibit reduced integrin-dependent adhesion and increased haptotaxis, migration and phagocytosis compared to wild-type mice

cellular
• basal and chemokine stimulated migration of T cells, B cells, myeloid cells, and bone marrow derived T cells, B cells and macrophages is decreased compared to wild-type cells

hematopoietic system
• basal and chemokine stimulated migration of T cells, B cells, myeloid cells, and bone marrow derived T cells, B cells and macrophages is decreased compared to wild-type cells
• neutrophils exhibit a reduced oxidative burst following stimulation with fMLP compared to similarly treated wild-type cells
• macrophages exhibit reduced integrin-dependent adhesion and increased haptotaxis, migration and phagocytosis compared to wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory