Phenotypes associated with this allele

• Allele Symbol: Apln^tm1Pngr
• Allele Name: targeted mutation 1, Josef M Penninger
• Allele ID: MGI:3813940
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apln^tm1Pngr/Apln^tm1Pngr	involves: 129P2/OlaHsd * C57BL/6	MGI:3813941
ot2	Apln^tm1Pngr/Y	involves: 129P2/OlaHsd * C57BL/6	MGI:3813943

Genotype
MGI:3813941

hm1

• Allelic Composition: Apln^tm1Pngr/Apln^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:140286 )

♀N • no abnormalities in cardiac development or heart structure are detected

decreased heart left ventricle muscle contractility ( J:140286 )

♀ • a decrease in left ventricle fractional shortening and increase in left ventricular diameter at systole are seen in mice at 6 months of age but not in mice at 3 months of age

♀ • decrease in function is more severe in 6 month old males compared to age matched females

behavior/neurological

behavior/neurological phenotype ( J:140286 )

♀N • despite data from experiments using exogenous administration of Apelin, no abnormalities in feeding behaviors or water intake are detected

growth/size/body

growth/size/body region phenotype ( J:140286 )

♀N • despite data from experiments using exogenous administration of Apelin, no abnormalities in weight gain are detected

muscle

decreased heart left ventricle muscle contractility ( J:140286 )

♀ • a decrease in left ventricle fractional shortening and increase in left ventricular diameter at systole are seen in mice at 6 months of age but not in mice at 3 months of age

♀ • decrease in function is more severe in 6 month old males compared to age matched females

Genotype
MGI:3813943

ot2

• Allelic Composition: Apln^tm1Pngr/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cardiovascular system

cardiovascular system phenotype ( J:140286 )

♂N • no abnormalities in cardiac development or heart structure are detected

decreased heart left ventricle muscle contractility ( J:140286 )

♂ • a decrease in left ventricle fractional shortening and increase in left ventricular diameter at systole are seen in mice at 6 months of age but not in mice at 3 months of age

♂ • decrease in function is more severe in 6 month old males compared to age matched females

♂ • decrease in function is more severe at 12 months of age

♂ • infusion of Apelin 13 peptides restores normal function in 6 month old mice

increased response of heart to induced stress ( J:140286 )

♂ • following aortic banding, mice display severe heart failure characterized by decreased fractional shortening and dilated left ventricle

behavior/neurological

behavior/neurological phenotype ( J:140286 )

♂N • despite data from experiments using exogenous administration of Apelin, no abnormalities in feeding behaviors or water intake are detected

growth/size/body

growth/size/body region phenotype ( J:140286 )

♂N • despite data from experiments using exogenous administration of Apelin, no abnormalities in weight gain are detected

muscle

decreased heart left ventricle muscle contractility ( J:140286 )

♂ • a decrease in left ventricle fractional shortening and increase in left ventricular diameter at systole are seen in mice at 6 months of age but not in mice at 3 months of age

♂ • decrease in function is more severe in 6 month old males compared to age matched females

♂ • decrease in function is more severe at 12 months of age

♂ • infusion of Apelin 13 peptides restores normal function in 6 month old mice

homeostasis/metabolism

increased response of heart to induced stress ( J:140286 )

♂ • following aortic banding, mice display severe heart failure characterized by decreased fractional shortening and dilated left ventricle