All Phenotypes Dcaf1<tm1.1Yxi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dcaf1^tm1.1Yxi
targeted mutation 1.1, Yue Xiong
MGI:3814062

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dcaf1^tm1.1Yxi/Dcaf1^tm1.2Yxi	involves: 129P2/OlaHsd * C57BL/6	MGI:3814066

Allelic Composition	Dcaf1^tm1.1Yxi/Dcaf1^tm1.2Yxi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcaf1^tm1.1Yxi mutation (1 available); any Dcaf1 mutation (70 available)
Dcaf1^tm1.2Yxi mutation (0 available); any Dcaf1 mutation (70 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:140246 )

• 96 hours after transduction of viral cre there is a substantial decrease in the S-phase cell population in MEFs

increased fibroblast apoptosis ( J:140246 )

• following transduction of viral cre there is a substantial increase in apoptosis in MEFs

decreased fibroblast proliferation ( J:140246 )

• following transduction of viral cre proliferation decreases by nearly 60% in MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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