About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dcaf1tm1.2Yxi
targeted mutation 1.2, Yue Xiong
MGI:3814063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dcaf1tm1.2Yxi/Dcaf1tm1.2Yxi involves: C57BL/6 MGI:3814065
cn2
 		Dcaf1tm1.1Yxi/Dcaf1tm1.2Yxi involves: 129P2/OlaHsd * C57BL/6 MGI:3814066


Genotype
MGI:3814065
hm1
Allelic
Composition		 Dcaf1tm1.2Yxi/Dcaf1tm1.2Yxi
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcaf1tm1.2Yxi mutation (0 available); any Dcaf1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3814066
cn2
Allelic
Composition		 Dcaf1tm1.1Yxi/Dcaf1tm1.2Yxi
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcaf1tm1.1Yxi mutation (1 available); any Dcaf1 mutation (70 available)
Dcaf1tm1.2Yxi mutation (0 available); any Dcaf1 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:140246 )
• 96 hours after transduction of viral cre there is a substantial decrease in the S-phase cell population in MEFs
increased fibroblast apoptosis ( J:140246 )
• following transduction of viral cre there is a substantial increase in apoptosis in MEFs
decreased fibroblast proliferation ( J:140246 )
• following transduction of viral cre proliferation decreases by nearly 60% in MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory