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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rom1Rgsc1156
RIKEN Genomic Sciences Center (GSC), 1156
MGI:3814074
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rom1Rgsc1156/Rom1Rgsc1156 involves: C57BL/6JJcl * DBA/2JJcl MGI:4443299
ht2
 		Rom1Rgsc1156/Rom1+ (DBA/2JJcl x C57BL/6JJcl)F1 MGI:4443297
ht3
 		Rom1Rgsc1156/Rom1+ involves: C57BL/6JJcl * DBA/2JJcl MGI:3814076


Genotype
MGI:4443299
hm1
Allelic
Composition		 Rom1Rgsc1156/Rom1Rgsc1156
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes
thin retina outer nuclear layer ( J:158048 )
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes
abnormal eye electrophysiology ( J:158048 )
• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age
• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes




Genotype
MGI:4443297
ht2
Allelic
Composition		 Rom1Rgsc1156/Rom1+
Genetic
Background		 (DBA/2JJcl x C57BL/6JJcl)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal ocular fundus morphology ( J:158048 )
• at 45 weeks of age
abnormal retina morphology ( J:158048 )
• at 45 weeks of age, retina are mottled unlike in wild-type mice
abnormal retina blood vessel morphology ( J:158048 )
• at 45 weeks of age, retinal arteries are narrower than in wild-type mice

cardiovascular system
abnormal retina blood vessel morphology ( J:158048 )
• at 45 weeks of age, retinal arteries are narrower than in wild-type mice




Genotype
MGI:3814076
ht3
Allelic
Composition		 Rom1Rgsc1156/Rom1+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes
thin retina outer nuclear layer ( J:158048 )
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes
retina degeneration ( J:133634 )
• observed in founder mouse at 16 weeks of age
abnormal eye electrophysiology ( J:158048 )
• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age
• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory