About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rom1Rgsc1156
RIKEN Genomic Sciences Center (GSC), 1156
MGI:3814074
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rom1Rgsc1156/Rom1Rgsc1156 involves: C57BL/6JJcl * DBA/2JJcl MGI:4443299
ht2
Rom1Rgsc1156/Rom1+ (DBA/2JJcl x C57BL/6JJcl)F1 MGI:4443297
ht3
Rom1Rgsc1156/Rom1+ involves: C57BL/6JJcl * DBA/2JJcl MGI:3814076


Genotype
MGI:4443299
hm1
Allelic
Composition
Rom1Rgsc1156/Rom1Rgsc1156
Genetic
Background
involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes
• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age
• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes




Genotype
MGI:4443297
ht2
Allelic
Composition
Rom1Rgsc1156/Rom1+
Genetic
Background
(DBA/2JJcl x C57BL/6JJcl)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 45 weeks of age
• at 45 weeks of age, retina are mottled unlike in wild-type mice
• at 45 weeks of age, retinal arteries are narrower than in wild-type mice

cardiovascular system
• at 45 weeks of age, retinal arteries are narrower than in wild-type mice




Genotype
MGI:3814076
ht3
Allelic
Composition
Rom1Rgsc1156/Rom1+
Genetic
Background
involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes
• observed in founder mouse at 16 weeks of age
• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age
• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory