About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rom1Rgsc1156
RIKEN Genomic Sciences Center (GSC), 1156
MGI:3814074
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rom1Rgsc1156/Rom1Rgsc1156 involves: C57BL/6JJcl * DBA/2JJcl MGI:4443299
ht2
 		Rom1Rgsc1156/Rom1+ (DBA/2JJcl x C57BL/6JJcl)F1 MGI:4443297
ht3
 		Rom1Rgsc1156/Rom1+ involves: C57BL/6JJcl * DBA/2JJcl MGI:3814076


Genotype
MGI:4443299
hm1
Allelic
Composition		 Rom1Rgsc1156/Rom1Rgsc1156
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes
thin retina outer nuclear layer ( J:158048 )
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes
abnormal eye electrophysiology ( J:158048 )
• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age
• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• worse than in heterozygotes




Genotype
MGI:4443297
ht2
Allelic
Composition		 Rom1Rgsc1156/Rom1+
Genetic
Background		 (DBA/2JJcl x C57BL/6JJcl)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal ocular fundus morphology ( J:158048 )
• at 45 weeks of age
abnormal retina morphology ( J:158048 )
• at 45 weeks of age, retina are mottled unlike in wild-type mice
abnormal retina blood vessel morphology ( J:158048 )
• at 45 weeks of age, retinal arteries are narrower than in wild-type mice

cardiovascular system
abnormal retina blood vessel morphology ( J:158048 )
• at 45 weeks of age, retinal arteries are narrower than in wild-type mice




Genotype
MGI:3814076
ht3
Allelic
Composition		 Rom1Rgsc1156/Rom1+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rom1Rgsc1156 mutation (1 available); any Rom1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes
thin retina outer nuclear layer ( J:158048 )
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes
retina degeneration ( J:133634 )
• observed in founder mouse at 16 weeks of age
abnormal eye electrophysiology ( J:158048 )
• in a single-flash electroretinogram, mice exhibit a reduction in a-wave and b-wave amplitude compared with wild-type mice that is more severe in homozygotes and worsens with age
• however, photopic eletroretinograms exhibit normal b-wave amplitude

nervous system
short photoreceptor outer segment ( J:158048 )
• at 7 weeks and worse at 35 weeks
• not as severe as in homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory