All Phenotypes Gt(ROSA)26Sor<tm1(Tva)Dsa> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	MGI:3814193
cn2	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3814192

Allelic Composition	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(Tva)Dsa mutation (1 available); any Gt(ROSA)26Sor mutation (968 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:140423 )

• median survival of mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, is only 151 days compared to 485 days for controls

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, display a significantly shorter latency of pancreatic ductal adenocarcinoma development

• all infected mice develop invasive pancreatic ductal adenocarcinoma within 10 months

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, display a significantly shorter latency of pancreatic ductal adenocarcinoma development

• all infected mice develop invasive pancreatic ductal adenocarcinoma within 10 months

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• 19 months after infection with RCASBP(A)-Kras^G12D retrovirus 3 of 5 mice developed invasive and metastatic pancreatic ductal adenocarcinomas with 2 of the 5 developing liver and lymph node metastases

• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

increased pancreatic intraepithelial neoplasia incidence ( J:140423 )

• 9 months after infection with RCASBP(A)-Kras^G12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias

increased incidence of induced tumors ( J:140423 )

• 9 months after infection with RCASBP(A)-Kras^G12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias

• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

increased pancreatic intraepithelial neoplasia incidence ( J:140423 )

• 9 months after infection with RCASBP(A)-Kras^G12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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