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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(Tva)Dsa
targeted mutation 1, Dieter Saur
MGI:3814188
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+ 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J MGI:3814193
cn2
 		Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+ 		involves: 129S6/SvEvTac * C57BL/6J MGI:3814192


Genotype
MGI:3814193
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Ptf1atm1(cre)Hnak/Ptf1a+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tva)Dsa mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1atm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:140423 )
• median survival of mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, is only 151 days compared to 485 days for controls

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:140423 )
• mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, display a significantly shorter latency of pancreatic ductal adenocarcinoma development
• all infected mice develop invasive pancreatic ductal adenocarcinoma within 10 months

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:140423 )
• mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, display a significantly shorter latency of pancreatic ductal adenocarcinoma development
• all infected mice develop invasive pancreatic ductal adenocarcinoma within 10 months




Genotype
MGI:3814192
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+
Ptf1atm1(cre)Hnak/Ptf1a+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tva)Dsa mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Ptf1atm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:140423 )
• 19 months after infection with RCASBP(A)-KrasG12D retrovirus 3 of 5 mice developed invasive and metastatic pancreatic ductal adenocarcinomas with 2 of the 5 developing liver and lymph node metastases
• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration
increased pancreatic intraepithelial neoplasia incidence ( J:140423 )
• 9 months after infection with RCASBP(A)-KrasG12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias
increased incidence of induced tumors ( J:140423 )
• 9 months after infection with RCASBP(A)-KrasG12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias
• 19 months after infection with RCASBP(A)-KrasG12D retrovirus 3 of 5 mice developed invasive and metastatic pancreatic ductal adenocarcinomas with 2 of the 5 developing liver and lymph node metastases
• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:140423 )
• 19 months after infection with RCASBP(A)-KrasG12D retrovirus 3 of 5 mice developed invasive and metastatic pancreatic ductal adenocarcinomas with 2 of the 5 developing liver and lymph node metastases
• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration
increased pancreatic intraepithelial neoplasia incidence ( J:140423 )
• 9 months after infection with RCASBP(A)-KrasG12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory