Phenotypes associated with this allele

• Allele Symbol: Trim2^{Gt(IRESBetageo)11Pgr}
• Allele Name: gene trap 11, Peter Gruss
• Allele ID: MGI:3814237
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim2^Gt(IRESBetageo)11Pgr/Trim2^Gt(IRESBetageo)11Pgr	involves: 129/Sv * C57BL/6	MGI:3814238

Genotype
MGI:3814238

hm1

• Allelic Composition: Trim2^{Gt(IRESBetageo)11Pgr}/Trim2^{Gt(IRESBetageo)11Pgr}
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:140337 )

• after 1.5 months, mice exhibit spontaneous generalized seizures

decreased Purkinje cell number ( J:140337 )

• at P50, mice exhibit a progressive and substantial (73%) loss of Purkinje cells in the anterior and posterior lobes of the vermis

• at 5 months of age, mice exhibit an 85% loss of Purkinje cells compared to in wild-type mice

• loss of Purkinje cells is due to apoptosis

abnormal cerebellum deep nucleus morphology ( J:140337 )

• at P45, deep cerebellar nuclei exhibit progressive neurodegeneration

abnormal axon morphology ( J:140337 )

• prior to neurodegeneration, axons of the optic nerve, brainstem, spinal cord and frontal cortex exhibit an accumulation of neurofilament-L and axonal swelling unlike in wild-type mice

decreased retina ganglion cell number ( J:140337 )

• at 4 months of age, the average number of ganglionic cells per 100 um is reduced by one-third compared to in wild-type mice

neurodegeneration ( J:140337 )

• at 4 months of age, mice exhibit neurodegeneration of the Purkinje cells, deep cerebellar nuclei and retinal ganglion cells

retina ganglion cell degeneration ( J:140337 )

• at 4 months of age, the average number of ganglionic cells per 100 um is reduced by one-third compared to in wild-type mice

behavior/neurological

tremors ( J:140337 )

• at 1.5 months, mice display an intention tremor followed by gait ataxia

ataxia ( J:140337 )

• at 1.5 months, mice display an intention tremor followed by gait ataxia

seizures ( J:140337 )

• after 1.5 months, mice exhibit spontaneous generalized seizures

vision/eye

decreased retina ganglion cell number ( J:140337 )

• at 4 months of age, the average number of ganglionic cells per 100 um is reduced by one-third compared to in wild-type mice

retina ganglion cell degeneration ( J:140337 )

• at 4 months of age, the average number of ganglionic cells per 100 um is reduced by one-third compared to in wild-type mice

thin retina inner nuclear layer ( J:140337 )

• at 4 months of age

thin retina outer plexiform layer ( J:140337 )

• at 4 months of age