Phenotypes associated with this allele

• Allele Symbol: Paxip1^L5Jcs4
• Allele Name: lethal 5 John C Schimenti 4
• Allele ID: MGI:3814326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Paxip1^L5Jcs4/Paxip1^L5Jcs4	involves: C57BL/6	MGI:3814334

Genotype
MGI:3814334

hm1

• Allelic Composition: Paxip1^L5Jcs4/Paxip1^L5Jcs4
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:100332 )

• embryos fail to develop past E3.5-E5.5 during the pre/peri-implantation stage

embryonic lethality during organogenesis, complete penetrance ( J:140559 )

• embryonic lethality occurs at E12.5

cardiovascular system

abnormal aortic arch development ( J:140559 )

• a well developed aortic arch does not form in E10.5 mutants

abnormal placenta vasculature ( J:140559 )

• placenta vasculature of E10.5 embryos lacks a properly developed capillary network or branching of large vessels

• placentas of E10.5 embryos have smaller diameter blood vessels and are fewer in number than in wild-type controls

abnormal vasculogenesis ( J:140559 )

• blood vessel networks fail to elaborate properly in the head of E10.5 embryos

abnormal vitelline vasculature morphology ( J:140559 )

• the yolk sacs of E10.5 embryos lack prominent vasculature

distended pericardium ( J:140559 )

• 40% of E9.5 embryos have an inflated pericardium

• E10.5 embryos have a swollen pericardial sac

embryo

abnormal placenta vasculature ( J:140559 )

• placenta vasculature of E10.5 embryos lacks a properly developed capillary network or branching of large vessels

• placentas of E10.5 embryos have smaller diameter blood vessels and are fewer in number than in wild-type controls

abnormal vitelline vasculature morphology ( J:140559 )

• the yolk sacs of E10.5 embryos lack prominent vasculature

decreased embryo size ( J:140559 )

• embryos are smaller than controls at E9.5

placental labyrinth hypoplasia ( J:140559 )

• the chorion-derived labyrinth layer is much smaller than in controls and is less well-defined

pale yolk sac ( J:140559 )

• the yolk sacs of E10.5 embryos are pale

growth/size/body

decreased embryo size ( J:140559 )

• embryos are smaller than controls at E9.5