Analysis Tools
mortality/aging
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• mice raised at a thermoneutral temperature exhibit a 50% survival rate at P35 whereas none of the mice raised at room temperature survive more than a few days passed weaning
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• at room temperature, mice die within days of weaning
• however, mice raised at thermoneutral temperature exhibit increased survival
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homeostasis/metabolism
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• at P10, P12 and P15, mice exhibit decreased body temperatures compared to wild-type mice
• however, hypothermia can be partially rescued by treatment with a blood brain barrier permeable muscarinic receptor antagonist and fully rescued with a potentiator of nicotinic receptors
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• mice cannot maintain their body temperatures as well as wild-type mice
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growth/size/body
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• around P15 to P17, mice exhibit slow postnatal weight gain
• however, mice raised in at a thermoneutral temperature exhibit normal weight gain
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adipose tissue
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• despite a reduction in white adipose tissue, the amount of brown adipose tissue is normal
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• at P15, mice exhibit a reduction in the ratio of white adipose tissue to body weight compared to in wild-type mice and by P20 white adipose tissue is almost completely depleted
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behavior/neurological
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• mice shiver at room temperature
• however, at a thermoneutral temperature mice do not shiver
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nervous system
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• mice exhibit a 40% decrease in nicotinic receptor currents in the sympathetic ganglia compared to in wild-type mice
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