Analysis Tools
cardiovascular system
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• mice exhibit artery abnormalities that are more severe than in Slc2a10S150F homozygotes older mice exhibit more severe phenotypes than younger mice
• central arteries in splenic white pulp exhibit thickened vessel wall with accumulation of elastic fibers in the internal elastic lamina and collagen fibers in the tunica adventitia unlike in wild-type mice
• however, cerebral arteries are normal at 10 months
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• artery adventitia exhibits an increase in collage fibers compared to in wild-type mice
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• artery walls are thickened and irregularly shaped compared to in wild-type mice
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• mice exhibit an increase in the number and size of elastic fibers compared with wild-type mice
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• at 10 months, endothelial and smooth muscle cells form small plaques in the lamina interna and media disrupting the internal elastic lamina membrane unlike in wild-type mice
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• thickened intima with hypertrophy
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• vessel walls in kidney arteries exhibit increased elastic fiber and zigzag-shaped internal elastic lamina compared to in wild-type mice
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• lung arterial walls and alveolar walls exhibit an increase in elastic fibers compared to in wild-type mice
• central arteries in splenic white pulp exhibit thickened vessel wall with accumulation of elastic fibers in the internal elastic lamina and collagen fibers in the tunica adventitia unlike in wild-type mice
• vessel walls in kidney arteries exhibit increased elastic fiber and zigzag-shaped internal elastic lamina compared to in wild-type mice
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• lung arterial walls exhibit an increase in elastic fibers compared to in wild-type mice
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immune system
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• spleen trabecula is widened where arteries, veins, nerves, and lymphatics travel in parallel compared to in wild-type mice
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renal/urinary system
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• vessel walls in kidney arteries exhibit increased elastic fiber and zigzag-shaped internal elastic lamina compared to in wild-type mice
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respiratory system
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• lung arterial walls exhibit an increase in elastic fibers compared to in wild-type mice
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• lung alveolar walls exhibit an increase in elastic fibers compared to in wild-type mice
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• increased elastic fibres along the arterial walls and alveolar walls of mutant lungs
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hematopoietic system
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• spleen trabecula is widened where arteries, veins, nerves, and lymphatics travel in parallel compared to in wild-type mice
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