Phenotypes associated with this allele

• Allele Symbol: Igh^tm1.1Hmj
• Allele Name: targeted mutation 1.1, Hans-Martin Jack
• Allele ID: MGI:3814340
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.1Hmj/Igh^tm1.1Hmj	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3814362

Genotype
MGI:3814362

hm1

• Allelic Composition: Igh^tm1.1Hmj/Igh^tm1.1Hmj
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:140486 )

N • B cells mature unexpectedly beyond the pro-B stage

abnormal B cell differentiation ( J:140486 )

• progression of B cells beyond the pro-B stage is dependent on Rag2 expresion

abnormal immunoglobulin heavy chain V(D)J recombination ( J:140486 )

• The VDJ segment is replaced with upstream varia ble Ig elements

decreased mature B cell number ( J:140486 )

• slightly reduced number of mature cell surface IGM-positive B cells in bone marrow

• number of IgM+ B cells in the spleen is reduced by 33%

spleen hypoplasia ( J:140486 )

• cellularity of the spleen is reduced 41%

hematopoietic system

abnormal B cell differentiation ( J:140486 )

• progression of B cells beyond the pro-B stage is dependent on Rag2 expresion

abnormal immunoglobulin heavy chain V(D)J recombination ( J:140486 )

• The VDJ segment is replaced with upstream varia ble Ig elements

decreased mature B cell number ( J:140486 )

• slightly reduced number of mature cell surface IGM-positive B cells in bone marrow

• number of IgM+ B cells in the spleen is reduced by 33%

spleen hypoplasia ( J:140486 )

• cellularity of the spleen is reduced 41%