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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac1tm1Atai
targeted mutation 1, Atsu Aiba
MGI:3814355
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Emx1tm1(cre)Ito/Emx1+
Rac1tm1Atai/Rac1tm1Jms 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR MGI:3814361


Genotype
MGI:3814361
cn1
Allelic
Composition		 Emx1tm1(cre)Ito/Emx1+
Rac1tm1Atai/Rac1tm1Jms
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Rac1tm1Atai mutation (0 available); any Rac1 mutation (24 available)
Rac1tm1Jms mutation (0 available); any Rac1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:140575 )
• fewer than expected mice are present at P18 but the remainder of mice survive into adulthood
postnatal lethality, incomplete penetrance ( J:140575 )
• fewer than expected mice are present at P18

nervous system
abnormal brain commissure morphology ( J:140575 )
• mice exhibit reduced formation of interhemispheric commissural connections by inhibition of midline crossing
• however, the posterior and habenular commissures are normal
abnormal corpus callosum morphology ( J:140575 )
• myelinated fibers are reduced in the corpus callosum and anterior commissure compared to in control (Rac1tm1Atai/Rac1+ Emx1tm1(cre)Ito/Emx1+) mice
• retrograde dye labeling experiments demonstrate that contralateral projections of the callosal commissural axons are absent
decreased anterior commissure size ( J:140575 )
• myelinated fibers are reduced in the corpus callosum and anterior commissure compared to in control (Rac1tm1Atai/Rac1+ Emx1tm1(cre)Ito/Emx1+) mice
abnormal telencephalon morphology ( J:140575 )
• neuron layers of the telencephalon cortex are thinner than in heterozygous controls (Rac1tm1Atai/Rac1+ Emx1tm1(cre)Ito/Emx1+) with sporadic distortions caused by abnormal cell clusters and nerve fibers
abnormal dentate gyrus morphology ( J:140575 )
• the dentate gyrus is disorganized
abnormal hippocampus pyramidal cell layer ( J:140575 )
• the pyramidal cell layer of the hippocampus is thinner than in control (Rac1tm1Atai/Rac1+ Emx1tm1(cre)Ito/Emx1+) mice
abnormal barrel cortex morphology ( J:140575 )
• somatosensory cortex barrels are small in size and irregular in shape compared to in control (Rac1tm1Atai/Rac1+ Emx1tm1(cre)Ito/Emx1+) mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory