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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stxbp5tm1Ytk
targeted mutation 1, Yoshimi Takai
MGI:3814545
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stxbp5tm1Ytk/Stxbp5tm1Ytk involves: 129X1/SvJ MGI:3814546
hm2
 		Stxbp5tm1Ytk/Stxbp5tm1Ytk involves: 129X1/SvJ * C57BL * C57BL/6 * DBA MGI:3814548
hm3
 		Stxbp5tm1Ytk/Stxbp5tm1Ytk involves: 129X1/SvJ * C57BL/6 MGI:3814547


Genotype
MGI:3814546
hm1
Allelic
Composition		 Stxbp5tm1Ytk/Stxbp5tm1Ytk
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp5tm1Ytk mutation (0 available); any Stxbp5 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:140649 )
• though fewer than expected mice are born the remainder appear healthy
prenatal lethality, incomplete penetrance ( J:140649 )
• fewer than expected mice are born




Genotype
MGI:3814548
hm2
Allelic
Composition		 Stxbp5tm1Ytk/Stxbp5tm1Ytk
Genetic
Background		 involves: 129X1/SvJ * C57BL * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp5tm1Ytk mutation (0 available); any Stxbp5 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal long-term potentiation ( J:140649 )
• the magnitude of long term potentiation is decreased during the first 20 minutes only




Genotype
MGI:3814547
hm3
Allelic
Composition		 Stxbp5tm1Ytk/Stxbp5tm1Ytk
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stxbp5tm1Ytk mutation (0 available); any Stxbp5 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:140649 )
• Background Sensitivity: no mice are born after three generation of backcrossing to C57BL/6




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory