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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(PDGFRA*)Hsc
targeted mutation 1, Hubert Schorle
MGI:3814559
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129/Sv * C57BL/6 * CBA MGI:3835760


Genotype
MGI:3835760
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(PDGFRA*)Hsc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(PDGFRA*)Hsc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the interfrontal bone is noticeably larger than controls starting at E16.5
• newborns have an overgrowth of the interfrontal bone in the anterior frontal calvaria
• the frontal bones of five day old mice are structured more trabecularly and have an increased portion of calcified bone matrix
• three-fold more osteprogenitors are actively proliferating within the frontal sutures of E19.5 fetuses compared to controls
• 1.4 fold more primary osteoblasts of calvaria tissue actively proliferate in vitro compared to controls
• all osteprogenitors from interfrontal bones differentiate into osteoblasts after three days in culture compared to only half of controls
• coronal suture closing begins 15 days after birth and is completed by 20 days of age
• premature fusion of the posterior frontal suture is seen at 5 days after birth
• by 10 days after birth, fusion of the anterior frontal suture becomes evident

craniofacial
• the interfrontal bone is noticeably larger than controls starting at E16.5
• newborns have an overgrowth of the interfrontal bone in the anterior frontal calvaria
• the frontal bones of five day old mice are structured more trabecularly and have an increased portion of calcified bone matrix
• a shortened craniofacial area is noticeable at one week after birth and worsens as the mice age

growth/size/body
• a shortened craniofacial area is noticeable at one week after birth and worsens as the mice age





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory