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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trpm7tm1.1Clph
targeted mutation 1.1, David E Clapham
MGI:3814706
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trpm7tm1.1Clph/Trpm7tm1.1Clph involves: 129S4/SvJae MGI:3814708
cn2
 		Trpm7tm1Clph/Trpm7tm1.1Clph
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:3814711
cn3
 		Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Lck-cre)548Jxm/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:3814863
cn4
 		Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Gata1-cre)1Sho/0 		involves: 129S4/SvJae * CD-1 MGI:3814709


Genotype
MGI:3814708
hm1
Allelic
Composition		 Trpm7tm1.1Clph/Trpm7tm1.1Clph
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpm7tm1.1Clph mutation (0 available); any Trpm7 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:140630 )
• no viable embryos were found, no time of lethality was provided




Genotype
MGI:3814711
cn2
Allelic
Composition		 Trpm7tm1Clph/Trpm7tm1.1Clph
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
Trpm7tm1.1Clph mutation (0 available); any Trpm7 mutation (102 available)
Trpm7tm1Clph mutation (1 available); any Trpm7 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:140630 )
• no viable embryos were found, no time of lethality was provided




Genotype
MGI:3814863
cn3
Allelic
Composition		 Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)548Jxm mutation (2 available)
Trpm7tm1.1Clph mutation (0 available); any Trpm7 mutation (102 available)
Trpm7tm1Clph mutation (1 available); any Trpm7 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus morphology ( J:140630 )
• 85% penetrance of thymic abnormalities
• CD3+ T cells are found distributed throughout the thymus
abnormal thymus cell ratio ( J:140630 )
• increase in the percentage and number of double negative T cells
• increase in the percentage of cells in the DN3 stage
abnormal thymus corticomedullary boundary morphology ( J:140630 )
• the boundary between the cortical and medullary regions is not well defined
abnormal thymus medulla morphology ( J:140630 )
• progressive loss of thymic medullary cells
decreased thymocyte number ( J:140630 )
• substantial reduction in the number of thymocytes
abnormal T cell differentiation ( J:140630 )
• partial block in the transition from double negative to double positive T cells
• block appears to be at the DN3 to DN4 transition as a significant proportion of cells fail to down regulate CD25
decreased T cell number ( J:140630 )
• slight decrease in the percentage and number of T cells in the spleen and lymph nodes but not in the intestine
abnormal T cell physiology ( J:140630 )
• thymocytes lack Mg2+ inhibitable current
• however, Mg2+ influx into freshly isolated T cells is unaffected

hematopoietic system
abnormal thymus morphology ( J:140630 )
• 85% penetrance of thymic abnormalities
• CD3+ T cells are found distributed throughout the thymus
abnormal thymus cell ratio ( J:140630 )
• increase in the percentage and number of double negative T cells
• increase in the percentage of cells in the DN3 stage
abnormal thymus corticomedullary boundary morphology ( J:140630 )
• the boundary between the cortical and medullary regions is not well defined
abnormal thymus medulla morphology ( J:140630 )
• progressive loss of thymic medullary cells
decreased thymocyte number ( J:140630 )
• substantial reduction in the number of thymocytes
abnormal T cell differentiation ( J:140630 )
• partial block in the transition from double negative to double positive T cells
• block appears to be at the DN3 to DN4 transition as a significant proportion of cells fail to down regulate CD25
decreased T cell number ( J:140630 )
• slight decrease in the percentage and number of T cells in the spleen and lymph nodes but not in the intestine
abnormal T cell physiology ( J:140630 )
• thymocytes lack Mg2+ inhibitable current
• however, Mg2+ influx into freshly isolated T cells is unaffected

endocrine/exocrine glands
abnormal thymus morphology ( J:140630 )
• 85% penetrance of thymic abnormalities
• CD3+ T cells are found distributed throughout the thymus
abnormal thymus cell ratio ( J:140630 )
• increase in the percentage and number of double negative T cells
• increase in the percentage of cells in the DN3 stage
abnormal thymus corticomedullary boundary morphology ( J:140630 )
• the boundary between the cortical and medullary regions is not well defined
abnormal thymus medulla morphology ( J:140630 )
• progressive loss of thymic medullary cells
decreased thymocyte number ( J:140630 )
• substantial reduction in the number of thymocytes




Genotype
MGI:3814709
cn4
Allelic
Composition		 Trpm7tm1Clph/Trpm7tm1.1Clph
Tg(Gata1-cre)1Sho/0
Genetic
Background		 involves: 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gata1-cre)1Sho mutation (2 available)
Trpm7tm1.1Clph mutation (0 available); any Trpm7 mutation (102 available)
Trpm7tm1Clph mutation (1 available); any Trpm7 mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:140630 )
• no viable embryos were found, no time of lethality was provided




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory