Analysis Tools
craniofacial
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• upper and lower incisors are chalky white, lacking the yellow iron pigmentation, unlike in wild-type mice
• in contrast, molars appear grossly normal
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• occasionally
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• the papillary region below the ameloblast separation exhibits increased cell proliferation compared to in wild-type mice
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• maturation stage ameloblasts are detached from the stratum intermedium
• fewer and smaller desmosomes are present at the stratum intermedium ameloblast interface than in wild-type mice
• ameloblasts fail to accumulate iron deposits in the supra-nuclear region with iron staining remaining diffuse unlike in wild-type cells
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• the enamel of incisors is hypomineralized
• howeevr, the expression pattern of enamel matrix proteins is normal
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• incisor enamel prism structure is less distinct than in wild-type mice
• the normal herring-bone pattern of hydroxyapatite prisms seen in wild-type incisors is absent
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• incisors show increased wear and fragility consistent with hypomineralization
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• lower incisors often show signs of excess mechanical attrition
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• lower incisors often show signs of fracture
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skeleton
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• upper and lower incisors are chalky white, lacking the yellow iron pigmentation, unlike in wild-type mice
• in contrast, molars appear grossly normal
|
|
• occasionally
|
|
• the papillary region below the ameloblast separation exhibits increased cell proliferation compared to in wild-type mice
|
|
• maturation stage ameloblasts are detached from the stratum intermedium
• fewer and smaller desmosomes are present at the stratum intermedium ameloblast interface than in wild-type mice
• ameloblasts fail to accumulate iron deposits in the supra-nuclear region with iron staining remaining diffuse unlike in wild-type cells
|
|
• the enamel of incisors is hypomineralized
• howeevr, the expression pattern of enamel matrix proteins is normal
|
|
• incisor enamel prism structure is less distinct than in wild-type mice
• the normal herring-bone pattern of hydroxyapatite prisms seen in wild-type incisors is absent
|
|
• incisors show increased wear and fragility consistent with hypomineralization
|
|
• lower incisors often show signs of excess mechanical attrition
|
|
• lower incisors often show signs of fracture
|
vision/eye
growth/size/body
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• upper and lower incisors are chalky white, lacking the yellow iron pigmentation, unlike in wild-type mice
• in contrast, molars appear grossly normal
|
|
• occasionally
|
|
• the papillary region below the ameloblast separation exhibits increased cell proliferation compared to in wild-type mice
|
|
• maturation stage ameloblasts are detached from the stratum intermedium
• fewer and smaller desmosomes are present at the stratum intermedium ameloblast interface than in wild-type mice
• ameloblasts fail to accumulate iron deposits in the supra-nuclear region with iron staining remaining diffuse unlike in wild-type cells
|
|
• the enamel of incisors is hypomineralized
• howeevr, the expression pattern of enamel matrix proteins is normal
|
|
• incisor enamel prism structure is less distinct than in wild-type mice
• the normal herring-bone pattern of hydroxyapatite prisms seen in wild-type incisors is absent
|
|
• incisors show increased wear and fragility consistent with hypomineralization
|
|
• lower incisors often show signs of excess mechanical attrition
|
|
• lower incisors often show signs of fracture
|
