Analysis Tools
immune system
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• B cells, but not dendritic cells or macrophages, are capable of inducing proliferation of CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch in vitro unlike wild-type cells
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation and instead undergo cell death
• mice are capable of inducing proliferation of memory T cells expressing Tg(Tcra2D2,Tcrb2D2)1Kuch unlike wild type mice
• mice are capable of inducing proliferation of Tg(Tcra2D2,Tcrb2D2)1Kuch T cells also deficient in Pdcd1 (Pdcd1tm1Hon) up to 71% or following treatment with anti-CTLA-4 antibodies up to 79% and proliferation is increased to 97% when both are used
• B cells induce peripheral tolerance by sensitizing T cells to antigen induced cell death in adoptive transfer experiments
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• mice are resistant to direct and passive MOG-induced experimental autoimmune encephalomyelitis (EAE) and can confer some resistance upon adoptive transfer of B cells into wild-type micemice are resistant to direct and passive MOG-induced experimental encephalomyelitis (EAE) and can confer some resistance upon adoptive transfer of B cells into wild-type mice
• resistance to EAE is not affected by depletion of T regulatory cells
• however, mice inoculated with C57BL/6 spinal cord fluid develop EAE
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hematopoietic system
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• B cells, but not dendritic cells or macrophages, are capable of inducing proliferation of CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch in vitro unlike wild-type cells
• unlike in vitro, when CD4+ T cells containing Tg(Tcra2D2,Tcrb2D2)1Kuch are transferred into mice they fail to exhibit proliferation and instead undergo cell death
• mice are capable of inducing proliferation of memory T cells expressing Tg(Tcra2D2,Tcrb2D2)1Kuch unlike wild type mice
• mice are capable of inducing proliferation of Tg(Tcra2D2,Tcrb2D2)1Kuch T cells also deficient in Pdcd1 (Pdcd1tm1Hon) up to 71% or following treatment with anti-CTLA-4 antibodies up to 79% and proliferation is increased to 97% when both are used
• B cells induce peripheral tolerance by sensitizing T cells to antigen induced cell death in adoptive transfer experiments
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