All Phenotypes Tg(TcraAV19AJ33)1Shima MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tcra^tm1Mom/Tcra^tm1Mom Tg(TcraAV19AJ33)1Shima/?	involves: 129S2/SvPas * C57BL/6	MGI:3814868
cx2	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tg(TcraAV19AJ33)1Shima/0	involves: 129S4/SvJae * C57BL/6	MGI:3831164
tg3	Tg(TcraAV19AJ33)1Shima/?	involves: 129S4/SvJae * C57BL/6	MGI:3814898

Allelic Composition	Tcra^tm1Mom/Tcra^tm1Mom Tg(TcraAV19AJ33)1Shima/?
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(TcraAV19AJ33)1Shima mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell morphology ( J:140924 )

• the only T cells present in the mice express a transgenic alpha chain that is associated with NK T cells

• Valpha 14 NK T cells are not present in these mice

• 30% of mononuclear cells in the liver are transgenic NK T cells

abnormal NK T cell physiology ( J:140924 )

• NK T cells respond to alpha-GalCer, a ligand normally associated with Valpha14 NK T cell activation

• the NK T cells are also reactive to alpha-ManCer

hematopoietic system

abnormal NK T cell morphology ( J:140924 )

• the only T cells present in the mice express a transgenic alpha chain that is associated with NK T cells

• Valpha 14 NK T cells are not present in these mice

• 30% of mononuclear cells in the liver are transgenic NK T cells

abnormal NK T cell physiology ( J:140924 )

• NK T cells respond to alpha-GalCer, a ligand normally associated with Valpha14 NK T cell activation

• the NK T cells are also reactive to alpha-ManCer

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain

• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time

• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

immune system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain

• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time

• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

increased interleukin-10 secretion ( J:112657 )

• transgenic NK T cells isolated from these mice induce IL-10 secretion from CD19⁺ B cells and other NK T cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:112657 )

• the progression and development of MOG-induced EAE is suppressed in these mice compared to both wild-type and Cd1d1/Cd1d2^tm1Crw homozygotes

• mean severity score is 1.3 versus 3.3 in wild-type controls

• mice at day 15 post induction have 3-fold less infiltrating mononuclear cells in their spinal cord with a lower percentage of CD4⁺ T cells making up the infiltrate (6% of infiltrating cells vs 21% in littermate controls)

• memory T cells isolated from mice 10 days after disease induction produce less inflammatory cytokines (IFN-g, TNF, IL-2 and IL-17) and more IL-10

• mean day of onset is 14.3 compared to 13.6 for wild-type controls

Allelic Composition	Tg(TcraAV19AJ33)1Shima/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are slightly higher with a normal number of Valpha14 NK T cells and slightly higher numbers of Valpha 19 NK T cells

abnormal NK T cell physiology ( J:112657 )

• NK T cells isolated from the liver secrete more TH-1 and TH-2 cytokines than NK T cells isolated from WT mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:112657 )

• the progression and development of MOG-induced EAE is suppressed in these mice

• mean day of onset is 18.6 compared to 13.6 for wild-type controls

• mean severity score is 1.3 versus 3.6 in wild-type controls

hematopoietic system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are slightly higher with a normal number of Valpha14 NK T cells and slightly higher numbers of Valpha 19 NK T cells

abnormal NK T cell physiology ( J:112657 )

• NK T cells isolated from the liver secrete more TH-1 and TH-2 cytokines than NK T cells isolated from WT mice

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