Phenotypes associated with this allele

• Allele Symbol: Tg(Foxn1-cre)1Tbo
• Allele Name: transgene insertion 1, Thomas Boehm
• Allele ID: MGI:3815021
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^+ Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440185
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Gt(ROSA)26Sor^tm1(Ctnnb1)Kem/Gt(ROSA)26Sor^tm1(Ctnnb1)Kem Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5440184
cn3	Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem Tg(Foxn1-cre)1Tbo/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5440186
cn4	Cbx4^tm1.1Gxu/Cbx4^tm1.2Gxu Tg(Foxn1-cre)1Tbo/0	involves: 129S2/SvPas * C57BL/6J	MGI:5489934
cn5	Wls^tm1.1Arte/Wls^tm1.1Arte Tg(Foxn1-cre)1Tbo/0	involves: C57BL/6	MGI:5547812

Genotype
MGI:5440185

cn1

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor⁺; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:187739 )

N • skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

focal hair loss ( J:187739 )

• broad stripes of hair loss are seen

• loss is followed by regrowth

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Genotype
MGI:5440184

cn2

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}/Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

integument

integument phenotype ( J:187739 )

N • skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sor^{tm1(Ctnnb1)Kem}

sparse hair ( J:187739 )

• thinner but continuous coat

growth/size/body

decreased body size ( J:187739 )

• at P14; however, mice catch up with littermate controls with age

Genotype
MGI:5440186

cn3

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2.1Kem; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

neonatal lethality, complete penetrance ( J:187739 )

• due to skin lesions

integument

skin lesions ( J:187739 )

Genotype
MGI:5489934

cn4

• Allelic Composition: Cbx4^tm1.1Gxu/Cbx4^tm1.2Gxu; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

hematopoietic system

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

abnormal lymphopoiesis ( J:194053 )

• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors

• however, the absolute number of B lineage cells in the thymus is similar to controls

decreased T cell number ( J:194053 )

• the T cell compartment in the periphery is never fully established in adult mice

• the CD3+ population in the spleen is small

decreased double-positive T cell number ( J:194053 )

• markedly reduced in proportion in the thymus at 3 weeks of age

• barely detectable at 6 weeks of age

immune system

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

abnormal lymphopoiesis ( J:194053 )

• the double negative population is over-represented and composed primarily of B220+ B lineage cells instead of T lineage precursors

• however, the absolute number of B lineage cells in the thymus is similar to controls

decreased double-positive T cell number ( J:194053 )

• markedly reduced in proportion in the thymus at 3 weeks of age

• barely detectable at 6 weeks of age

decreased T cell number ( J:194053 )

• the T cell compartment in the periphery is never fully established in adult mice

• the CD3+ population in the spleen is small

endocrine/exocrine glands

abnormal thymus development ( J:194053 )

• expression analysis indicates a defect in the maturation of both medullary and cortical epithelial cells

thymus atrophy ( J:194053 )

• limited thymic epithelial architecture quickly deteriorates in postnatal mice with discrete cortical and medullary structures no longer seen at 3 weeks of age

thymus hypoplasia ( J:194053 )

• severe

abnormal thymus physiology ( J:194053 )

• expression analysis indicates impaired proliferation of developing epithelial cells

Genotype
MGI:5547812

cn5

• Allelic Composition: Wls^tm1.1Arte/Wls^tm1.1Arte; Tg(Foxn1-cre)1Tbo/0
• Genetic Background: involves: C57BL/6

integument

integument phenotype ( J:202499 )

N • mice do not develop skin inflammation

sparse hair ( J:202499 )

• slightly less dense hair

immune system

immune system phenotype ( J:202499 )

N • mice do not develop skin inflammation