Phenotypes associated with this allele

• Allele Symbol: Cxadr^tm2Know
• Allele Name: targeted mutation 2, Kirk U Knowlton
• Allele ID: MGI:3815069
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxadr^tm2Know/Cxadr^tm2Know	involves: 129 * Black Swiss	MGI:3815089
ht2	Cxadr^tm2Know/Cxadr^+	involves: 129 * Black Swiss	MGI:3815093

Genotype
MGI:3815089

hm1

• Allelic Composition: Cxadr^tm2Know/Cxadr^tm2Know
• Genetic Background: involves: 129 * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:140870 )

• embryos generally die between E11.5 and E12.5

cardiovascular system

pericardial effusion ( J:140870 )

• some embryos have evidence of hemorrhage and a large pericardial effusion at E10.5-E11.5

absent heartbeat ( J:140870 )

• the heartbeat stops in embryos by E12.5

abnormal heart electrocardiography waveform feature ( J:140870 )

• the interval between the beginning of the A-wave and the beginning of the aortic outflow (a proxy for PR interval) is reduced by a third in all E10.5-E11.5 embryos

homeostasis/metabolism

pericardial effusion ( J:140870 )

• some embryos have evidence of hemorrhage and a large pericardial effusion at E10.5-E11.5

Genotype
MGI:3815093

ht2

• Allelic Composition: Cxadr^tm2Know/Cxadr⁺
• Genetic Background: involves: 129 * Black Swiss

cardiovascular system

abnormal heart electrocardiography waveform feature ( J:140870 )

• the interval between the beginning of the A-wave and the beginning of the aortic outflow (a proxy for PR interval) is reduced by a third in E10.5-E11.5 embryos