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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc32a1tm1Lowl
targeted mutation 1, Bradford B Lowell
MGI:3815083
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Agrptm1(cre)Lowl/Agrp+
Slc32a1tm1Lowl/Slc32a1tm1Lowl
involves: 129S6/SvEvTac * C57BL/6 MGI:3815087
cn2
Agrptm1(cre)Lowl/Agrp+
Slc32a1tm1Lowl/Slc32a1tm1Lowl
Tg(Pomc1-hrGFP)1Lowl/0
involves: 129S6/SvEvTac * FVB/N MGI:5142231


Genotype
MGI:3815087
cn1
Allelic
Composition
Agrptm1(cre)Lowl/Agrp+
Slc32a1tm1Lowl/Slc32a1tm1Lowl
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Slc32a1tm1Lowl mutation (1 available); any Slc32a1 mutation (55 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

growth/size/body
• in both males and females on a normal chow diet
• decrease in weight gain when place on a high fat diet

adipose tissue
• decrease in weight gain on a high fat diet is solely the result of reduced fat accumulation

behavior/neurological
• attenuated response to gherlin induced increase in food intake
• however, no difference in baseline food intake is detected
• increased locomotor activity

homeostasis/metabolism
• decrease in weight gain when place on a high fat diet
• on a normal chow diet
• during the transition from a normal chow diet to a high fat diet there is a larger increase in oxygen consumption compared to controls




Genotype
MGI:5142231
cn2
Allelic
Composition
Agrptm1(cre)Lowl/Agrp+
Slc32a1tm1Lowl/Slc32a1tm1Lowl
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Slc32a1tm1Lowl mutation (1 available); any Slc32a1 mutation (55 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory