Phenotypes associated with this allele

• Allele Symbol: Agrp^tm1(cre)Lowl
• Allele Name: targeted mutation 1, Bradford B Lowell
• Allele ID: MGI:3815085
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp^+	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543678
cn2	Agrp^tm1(cre)Lowl/Agrp^+ Lepr^tm1.1Chua/Lepr^tm1.1Chua	involves: 129S6/SvEvTac	MGI:5142228
cn3	Agrp^tm1(cre)Lowl/Agrp^+ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl	involves: 129S6/SvEvTac * C57BL/6	MGI:3815087
cn4	Agrp^tm1(cre)Lowl/Agrp^+ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl Tg(Pomc1-hrGFP)1Lowl/0	involves: 129S6/SvEvTac * FVB/N	MGI:5142231
cn5	Agrp^tm1(cre)Lowl/Agrp^+ Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-hrGFP)1Lowl/0	involves: 129S6/SvEvTac * FVB/N	MGI:5142229

Genotype
MGI:5543678

cn1

• Allelic Composition: Rock1^tm1.1Itl/Rock1^tm1.1Itl; Agrp^tm1(cre)Lowl/Agrp⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

increased epididymal fat pad weight ( J:204885 )

increased mesenteric fat pad weight ( J:204885 )

increased renal fat pad weight ( J:204885 )

• perirenal

growth/size/body

increased body weight ( J:204885 )

obese ( J:204885 )

Genotype
MGI:5142228

cn2

• Allelic Composition: Agrp^tm1(cre)Lowl/Agrp⁺; Lepr^tm1.1Chua/Lepr^tm1.1Chua
• Genetic Background: involves: 129S6/SvEvTac

nervous system

nervous system phenotype ( J:174691 )

N • no change in spontaneous IPSC amplitude or frequency is observed in Pomc1 neurons in slices

Genotype
MGI:3815087

cn3

• Allelic Composition: Agrp^tm1(cre)Lowl/Agrp⁺; Slc32a1^tm1Lowl/Slc32a1^tm1Lowl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

nervous system

abnormal inhibitory postsynaptic currents ( J:140858 )

• absent in AgRP neurons

growth/size/body

decreased body weight ( J:140858 )

• in both males and females on a normal chow diet

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

adipose tissue

decreased total body fat amount ( J:140858 )

• decrease in weight gain on a high fat diet is solely the result of reduced fat accumulation

behavior/neurological

abnormal food intake ( J:140858 )

• attenuated response to gherlin induced increase in food intake

• however, no difference in baseline food intake is detected

increased locomotor activity ( J:140858 )

• increased locomotor activity

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

increased oxygen consumption ( J:140858 )

• on a normal chow diet

• during the transition from a normal chow diet to a high fat diet there is a larger increase in oxygen consumption compared to controls

decreased respiratory quotient ( J:140858 )

• reduced

Genotype
MGI:5142231

cn4

• Allelic Composition: Agrp^tm1(cre)Lowl/Agrp⁺; Slc32a1^tm1Lowl/Slc32a1^tm1Lowl; Tg(Pomc1-hrGFP)1Lowl/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

nervous system

nervous system phenotype ( J:174691 )

N • addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations

Genotype
MGI:5142229

cn5

• Allelic Composition: Agrp^tm1(cre)Lowl/Agrp⁺; Lepr^tm1.1Chua/Lepr^tm1.1Chua; Tg(Pomc1-hrGFP)1Lowl/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

nervous system

nervous system phenotype ( J:174691 )

N • addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations