Phenotypes associated with this allele

• Allele Symbol: Nr1i3^{tm1(NR1I3)Arte}
• Allele Name: targeted mutation 1, TaconicArtemis
• Allele ID: MGI:3815103
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1i3^tm1(NR1I3)Arte/Nr1i3^tm1(NR1I3)Arte	involves: C57BL/6	MGI:3815125

Genotype
MGI:3815125

hm1

• Allelic Composition: Nr1i3^{tm1(NR1I3)Arte}/Nr1i3^{tm1(NR1I3)Arte}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:140975 )

N • mice exhibit normal survival

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:140975 )

• mice exhibit decreased induction of Cyp2b10 and Cyp3a11 expression TCPOBOP (1,4-bis[2-(3,5-dichloropyridyloxy)]benzene) compared to similarly treated wild-type mice

increased physiological sensitivity to xenobiotic ( J:140975 )

• mice exhibit increased induction of Cyp2b10 and Cyp3a11 expression following treatment with CITCO (6-(4-chlorophenyl)imidazo-[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichloro-benzyl)oxime) compared to similarly treated wild-type mice

abnormal xenobiotic pharmacokinetics ( J:140975 )

• following treatment with CITCO (6-(4-chlorophenyl)imidazo-[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichloro-benzyl)oxime), mice exhibit increased clearance of midazolam and buproprion compared to similarly treated wild-type mice

liver/biliary system

liver/biliary system phenotype ( J:140975 )

N • mice exhibit normal liver histology

reproductive system

reproductive system phenotype ( J:140975 )

N • mice exhibit normal fertility