homeostasis/metabolism
• compared to wild-type mice when fed a standard or high fat diet
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• compared to wild-type mice when fed a high fat diet
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• compared to wild-type mice when fed a standard or high fat diet
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• when fed a high fat diet mice weigh less than wild-type mice
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• compared to wild-type mice when fed a standard or high fat diet
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• when fed a high fat diet, mice exhibit an increased respiratory quotient compared to wild-type mice
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• when fed a standard or high fat diet, mice exhibit improved glucose tolerance compared to similarly treated wild-type mice
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• basal rates of lipolysis are increased compared to in wild-type adipocytes
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adipose tissue
• brown adipocyte fat droplets are larger than in wild-type mice
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• epididymal adipose tissue is brown in color unlike in wild-type mice
• subcutaneous and epididymal white adipocytes exhibit multilocular fat droplets that are smaller than in wild-type mice
• white adipocytes have twice as many mitochondria per cell as in wild-type mice
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• epididymal and subcutaneous white adipose tissue are less than in wild-type mice
• when fed a high fat diet, mice did not exhibit as much of an increase in adipose tissue as wild-type mice
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growth/size/body
• at 16 weeks, mice weigh less than wild-type mice
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• when fed a high fat diet mice weigh less than wild-type mice
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liver/biliary system
• compared to wild-type mice when fed a high fat diet
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integument