Analysis Tools
homeostasis/metabolism
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• 4 weeks after cuff placement, mice exhibit reduced arterial intima thickening compared to in similarly treated wild-type mice with average I/M ratio 32% of wild-type
• after cuff placement and treatment angiotensinogen, mice fail to exhibit an increase in intima thickening observed similarly treated wild-type mice
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muscle
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• vascular smooth muscle cells exhibit reduced migration, invasion and attachment when cultured with PDGF-BB compared to wild-type cells
• however, smooth muscle cell proliferation when cultured with PDGF-BB is normal
• smooth muscle cells do not respond to angiotensinogen as a chemoattractant nor do they exhibit membrane ruffling unlike similarly treated wild-type cells unless treated with wild-type cell conditioned media
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cardiovascular system
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• vascular smooth muscle cells exhibit reduced migration, invasion and attachment when cultured with PDGF-BB compared to wild-type cells
• however, smooth muscle cell proliferation when cultured with PDGF-BB is normal
• smooth muscle cells do not respond to angiotensinogen as a chemoattractant nor do they exhibit membrane ruffling unlike similarly treated wild-type cells unless treated with wild-type cell conditioned media
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• 4 weeks after cuff placement, mice exhibit reduced arterial intima thickening compared to in similarly treated wild-type mice with average I/M ratio 32% of wild-type
• after cuff placement and treatment angiotensinogen, mice fail to exhibit an increase in intima thickening observed similarly treated wild-type mice
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