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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prm3tm1Grz
targeted mutation 1, Pawel Grzmil
MGI:3815297
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prm3tm1Grz/Prm3tm1Grz involves: 129/Sv * C57BL/6 MGI:3815298


Genotype
MGI:3815298
hm1
Allelic
Composition		 Prm3tm1Grz/Prm3tm1Grz
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prm3tm1Grz mutation (0 available); any Prm3 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:140818 )
N
• despite reduced sperm motility, males are fertile and are just as likely to sire litters as wild-type males in competitive breeding assays
abnormal sperm motility ( J:140818 )
• in vitro studies found reduced motility in the following parameters 3.5 hours after sperm collection: lateral head displacement, beat cross frequency, average path velocity, straight line velocity, and curvilinear velocity
• after 5.5 h of incubation, no significant difference between mutant and wild-type sperm is observed

cellular
abnormal sperm motility ( J:140818 )
• in vitro studies found reduced motility in the following parameters 3.5 hours after sperm collection: lateral head displacement, beat cross frequency, average path velocity, straight line velocity, and curvilinear velocity
• after 5.5 h of incubation, no significant difference between mutant and wild-type sperm is observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory